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dc.contributor.author정상훈-
dc.contributor.author안홍열-
dc.contributor.author양재욱-
dc.contributor.author김지영-
dc.contributor.author이창용-
dc.contributor.author김태진-
dc.date.accessioned2021-06-09T04:23:18Z-
dc.date.available2021-06-09T04:23:18Z-
dc.date.issued2019-10-
dc.identifier.citationVOL 20, NO 21-5268-17-
dc.identifier.issn1422-0067-
dc.identifier.other53739-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/70362-
dc.description.abstractThe aim of this study was to evaluate the pharmacological efficacy of persimmon leaves in two glaucoma models, microbeads-induced ocular hypertension (OHT) and DBA/2 mouse. Thus, we demonstrated that Ethanol Extract of Diospyros kaki (EEDK) reduced elevated intraocular pressure (IOP) in both mouse models of glaucoma by measurements with a tonometer. In particular, we revealed that retinal ganglion cell loss and optic nerve damage caused by IOP elevation were markedly diminished as assessed by TUNEL assay, H&E staining, and fluorescent staining, while the expression of soluble guanylate cyclase (sGCα-1) increased, when EEDK was administered, as revealed by western blot. Moreover, the b-wave magnitude indicating functional scotopic vision was significantly improved in EEDK-administered DBA/2 mice during the 10-week follow-up study, as observed with electroretinography. Collectively, our results suggested that EEDK could be an effective therapeutic and IOP-lowering agent for preventing and treating retinal degenerative diseases such as glaucoma.-
dc.publisherInternational journal of molecular sciences-
dc.subjectGlaucoma-
dc.subjectIntraocular pressure-
dc.subjectnatural product-
dc.subjectpersimmon leave-
dc.titleThe Intraocular Pressure-Lowering Effect of Persimmon leaves (Diospyros kaki) in a Mouse Model of Glaucoma-
dc.typeArticle-
dc.relation.page5268-15268-17-
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