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dc.contributor.author권익찬-
dc.contributor.author김선화-
dc.contributor.author양유수-
dc.contributor.author곽기정-
dc.contributor.author김효석-
dc.contributor.author왕선영-
dc.date.accessioned2021-06-09T04:23:32Z-
dc.date.available2021-06-09T04:23:32Z-
dc.date.issued2019-10-
dc.identifier.citationVOL 6, NO 20-1900513--
dc.identifier.issn2198-3844-
dc.identifier.other53973-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/70581-
dc.description.abstractMacrophages (M&#981-
dc.description.abstracts) critically contribute to wound healing by coordinating inflammatory, proliferative, and angiogenic processes. A proper switch from proinflammatory M1 to anti&#8208-
dc.description.abstractinflammatory M2 dominant M&#981-
dc.description.abstracts accelerates the wound healing processes leading to favorable wound&#8208-
dc.description.abstractcare outcomes. Herein, an exosome&#8208-
dc.description.abstractguided cell reprogramming technique is proposed to directly convert M1 to M2 M&#981-
dc.description.abstracts for effective wound management. The M2 M&#981-
dc.description.abstract&#8208-
dc.description.abstractderived exosomes (M2&#8208-
dc.description.abstractExo) induce a complete conversion of M1 to M2 M&#981-
dc.description.abstracts in vitro. The reprogrammed M2 M&#981-
dc.description.abstracts turn Arginase (M2&#8208-
dc.description.abstractmarker) and iNOS (M1&#8208-
dc.description.abstractmarker) on and off, respectively, and exhibit distinct phenotypic and functional features of M2 M&#981-
dc.description.abstracts. M2&#8208-
dc.description.abstractExo has not only M&#981-
dc.description.abstractreprogramming factors but also various cytokines and growth factors promoting wound repair. After subcutaneous administration of M2&#8208-
dc.description.abstractExo into the wound edge, the local populations of M1 and M2 M&#981-
dc.description.abstracts are markedly decreased and increased, respectively, showing a successful exosome&#8208-
dc.description.abstractguided switch to M2 M&#981-
dc.description.abstractpolarization. The direct conversion of M1 to M2 M&#981-
dc.description.abstracts at the wound site accelerates wound healing by enhancing angiogenesis, re&#8208-
dc.description.abstractepithelialization, and collagen deposition. The M&#981-
dc.description.abstractphenotype switching induced by exosomes possessing the excellent cell reprogramming capability and innate biocompatibility can be a promising therapeutic approach for various inflammation&#8208-
dc.description.abstractassociated disorders by regulating the balance between pro&#8208-
dc.description.abstractversus anti&#8208-
dc.description.abstractinflammatory M&#981-
dc.description.abstracts.-
dc.publisherAdvanced science-
dc.titleExosome­guided phenotypic switch of M1 to M2 macrophages for cutaneous wound healing-
dc.typeArticle-
dc.relation.page1900513-11900513--
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