Label-free and real-time detection of avian influenza using nanowire field effect transistors
- Label-free and real-time detection of avian influenza using nanowire field effect transistors
- 임매순; 안재혁; 박태정; 이상엽; 최양규
- Issue Date
- Journal of biomedical nanotechnology
- VOL 11, NO 9-1643
- Real-time and label-free detection of antibodies from avian influenza (anti-AI) in an aqueous solution is demonstrated with the use of a nanowire field effect transistor. A real-time measurement system is constructed without leakage paths through the solution medium. The current through the nanowire changes significantly after an injection of an anti-AI solution onto the device, which was previously functionalized by the antigen of AI as a probe of anti-AI. In contrast, no significant response arises when an anti-AI solution is injected onto a non-functionalized device. Therefore, the real-time detection of specific antibody-antigen interaction of the AI is successfully implemented for a chip-based biosensor.
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