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dc.contributor.author이충구-
dc.contributor.author강이중-
dc.contributor.author오은정-
dc.contributor.author조찬미-
dc.contributor.author권호근-
dc.contributor.author전지민-
dc.contributor.author이혜미-
dc.contributor.author최상일-
dc.contributor.author한성재-
dc.contributor.author남지호-
dc.contributor.author송치은-
dc.contributor.author정현호-
dc.contributor.author김혜영-
dc.contributor.author박은정-
dc.contributor.author최은주-
dc.contributor.author김주영-
dc.contributor.author윤성일-
dc.contributor.author양시영-
dc.date.accessioned2021-06-09T04:24:12Z-
dc.date.available2021-06-09T04:24:12Z-
dc.date.issued2020-03-
dc.identifier.citationVOL 10-5603-13-
dc.identifier.issn2045-2322-
dc.identifier.other54640-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/71159-
dc.description.abstract3′-Sialyllactose (3′-SL), a natural prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. Although regulatory T cells (Tregs) prevent excessive inflammation and maintain immune tolerance, the effect of 3′-SL on Treg regulation is unclear. This study aimed to investigate the effect of 3′-SL on Treg responses in atopic dermatitis (AD) pathogenesis. Oral administration of 3′-SL reduced AD-like symptoms such as ear, epidermal, and dermal thickness in repeated topical application of house dust mites (HDM) and 2,4-dinitrochlorobenzene (DNCB). 3′-SL inhibited IgE, IL-1β, IL-6, and TNF-α secretion and markedly downregulated AD-related cytokines including IL-4, IL-5, IL-6, IL-13, IL-17, IFN-γ, TNF-α, and Tslp through regulation of NF-κB in ear tissue. Additionally, in vitro assessment of Treg differentiation revealed that 3′-SL directly induced TGF-β-mediated Treg differentiation. Furthermore, 3′-SL administration also ameliorated sensitization and elicitation of AD pathogenesis by suppressing mast cell infiltration and production of IgE and pro-inflammatory cytokines in mouse serum by mediating the Treg response. Furthermore, Bifidobacterium population was also increased by 3′-SL administration as prebiotics. Our data collectively show that 3′-SL has therapeutic effects against AD progression by inducing Treg differentiation, downregulating AD-related cytokines, and increasing the Bifidobacterium population.-
dc.publisherScientific Reports-
dc.subjectPrebiotics-
dc.subjectSkin inflammation-
dc.subjectRegulatory T cells-
dc.subjectAtopic dermatitis-
dc.subjectMicrobiome-
dc.subjectGut-
dc.title3′-Sialyllactose prebiotics prevents skin inflammation via regulatory T cell differentiation in atopic dermatitis mouse models-
dc.typeArticle-
dc.relation.page5603-15603-13-
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