Degradable polyphosphoester-based silver-loaded nanoparticles as therapeutics for bacterial lung infections
- Degradable polyphosphoester-based silver-loaded nanoparticles as therapeutics for bacterial lung infections
- 조상호; Fuwu Zhang; Justin A. Smolen; Shiyi Zhang; Richen Li; Parth N. Shah; Hai Wang; Jerrery E. Raymond; Carolyn L. Cannon; Karen L. Wooley
- Issue Date
- VOL 7, NO 6-2270
- In this study, a new type of degradable polyphosphoester-based polymeric nanoparticle, capable of carrying silver cations via interactions with alkyne groups, has been developed as a potentially effective and safe treatment for lung infections. It was found that up to 15% (w/w) silver loading into the nanoparticles could be achieved, consuming most of the pendant alkyne groups along the backbone, as revealed by Raman spectroscopy. The well-defined Ag-loaded nanoparticles released silver in a controlled and sustained manner over 5 days, and displayed enhanced in vitro antibacterial activities against cystic fibrosis-associated pathogens and decreased cytotoxicity to human bronchial epithelial cells, in comparison to silver acetate.
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