A local difference in blood-brain barrier permeability in the caudate putamen and thalamus of a rat brain induced by focused ultrasound
- A local difference in blood-brain barrier permeability in the caudate putamen and thalamus of a rat brain induced by focused ultrasound
- 김형민; 박기주; 박태영; Hyungkyu Huh; Hyeon Seo; Mun Han; Byeongjin Jung; Hyo Jin Choi; Eun-Hee Lee; Juyoung Park
- focused ultrasound; blood-brain barrier opening; acoustic simulation
- Issue Date
- Scientific Reports
- VOL 10, 19286
- A blood？brain barrier (BBB) opening induced by focused ultrasound (FUS) has been widely studied as an efective way of treating brain diseases. We investigate the efect of ultrasound’s incidence angle at caudate putamen (Cp) and thalamus (Th) of the rat brain by inducing the same power of focused ultrasound that corresponds to the acoustic pressure of 0.65 MPa in free feld. The BBB permeability (Ktrans) was quantitatively evaluated with dynamic contrast-enhanced magnetic resonance imaging. The group averaged (n= 11) maximum Ktrans at Cp (0.021 ± 0.012 min？1) was 1.39 times smaller than the Ktrans of Th (0.029 ± 0.01 min？1) with p= 0.00343. The group averaged (n= 6) ultrasound’s incidence angles measured using the computed tomography image of rat skulls were compared with the maximum Ktrans and showed a negatively linear relation R2 = 0.7972). The maximum acoustic pressure computed from the acoustic simulation showed higher average acoustic pressures at Th (0.37 ± 0.02 MPa) compared to pressures at Cp (0.32 ± 0.01 MPa) with p= 0.138 × 10？11. More red blood cell were observed at the Th region compared to the Cp region in the tissue staining. These results indicate that localized characteristics of the sonication target within the subject should be considered for safer and more efcient BBB disruption induced by FUS.
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