Self-detachable UV-curable polymers for open-access microfluidic platforms
- Self-detachable UV-curable polymers for open-access microfluidic platforms
- 김진현; 김홍남; 방석영; Dongha Tahk; Sujin Hyung; Jungeun Lim; James Yu; Noo Li Jeon
- Issue Date
- Lab on a chip
- VOL 20, NO 22-4224
- This study presents an ultraviolet (UV)-curable polymer which is applicable to open-access microfluidic platforms. The UV-curable polymer was prepared by mixing trimethylolpropane triacrylate (TMPTA), 1,6-hexanediol diacrylate (HDDA), polyethylene glycol-diacrylate (PEG-DA), and Irgacure 184. The polymer resin is optically transparent before and after UV-assisted curing and showed good biocompatibility when culturing multiple types of cells on the nanopatterned polymer substrate. The polymer has good adhesion with poly(dimethylsiloxane) (PDMS) even under large deformation and showed a low swelling ratio when exposed to water, suggesting a possibility to be used as a substrate for an organ on a chip. Furthermore, because the polymers have controllable hydrolysis ability depending on the composition, long-term 3D cell culture and subsequent biological analysis with harvested cells are possible. The self-detachable synthesized UV-curable polymer may help the advancement of biomedical studies using in vitro cell culture.
- Appears in Collections:
- KIST Publication > Article
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.