A self-assembled DNA tetrahedron as a carrier for in vivo liver-specific delivery of siRNA
- A self-assembled DNA tetrahedron as a carrier for in vivo liver-specific delivery of siRNA
- 안대로; 김정현; 김경란; 제갈현
- Issue Date
- Biomaterials Science
- VOL 8, NO 2-590
- While siRNA is a potent therapeutic tool that can silence disease-causing mRNA, its in vivo potency can be compromised due to the lack of target tissue specificity. Here, we report a wireframe tetrahedral DNA nanostructure having a 20-mer duplex on each side that can be specifically distributed into the liver upon systemic administration. This liver-targeted DNA tetrahedron is employed as the carrier for liver-specific delivery of siRNA targeting ApoB1 mRNA, which is overexpressed in hypercholesterolemia. When delivered by a DNA tetrahedron, the siRNA can preferentially be accumulated in the liver and down-regulate the ApoB1 protein. As a result, the blood cholesterol level is also decreased by the siRNA. These results successfully demonstrate that the DNA tetrahedron is a promising carrier for liver-targeted delivery of therapeutic nucleic acids.
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