Pharmacogenomic analysis of patient-derived tumor cells in gynecologic cancers
- Pharmacogenomic analysis of patient-derived tumor cells in gynecologic cancers
- 안형준; 사 제이슨; 황재령; 조영재; 류지윤; 최정주; 정수영; 김지혜; 김명선; 백은선; 이유영; 최철헌; 김태중; 김병기; 배덕수; 이예리; 허남구; 신용재; 조희진; 김자연; 서윤지; 구하림; 오정우; 이태범; 김현수; 송상용; 배준설; 박웅양; 한희동; 아닐 수드; 라울 라바단; 이진구; 남도현; 이정원
- ovarian cancer; pharmacogenomic analysis; patient-derived tumor cell; anticancer effect; drug response
- Issue Date
- Genome Biology
- VOL 20, NO 253-13
- Background: Gynecologic malignancy is one of the leading causes of mortality in female adults worldwide.
Comprehensive genomic analysis has revealed a list of molecular aberrations that are essential to tumorigenesis,
progression, and metastasis of gynecologic tumors. However, targeting such alterations has frequently led to
treatment failures due to underlying genomic complexity and simultaneous activation of various tumor cell survival
pathway molecules. A compilation of molecular characterization of tumors with pharmacological drug response is
the next step toward clinical application of patient-tailored treatment regimens.
Results: Toward this goal, we establish a library of 139 gynecologic tumors including epithelial ovarian cancers (EOCs),
cervical, endometrial tumors, and uterine sarcomas that are genomically and/or pharmacologically annotated and explore
dynamic pharmacogenomic associations against 37 molecularly targeted drugs. We discover lineage-specific drug
sensitivities based on subcategorization of gynecologic tumors and identify TP53 mutation as a molecular determinant
that elicits therapeutic response to poly (ADP-Ribose) polymerase (PARP) inhibitor. We further identify transcriptome
expression of inhibitor of DNA biding 2 (ID2) as a potential predictive biomarker for treatment response to olaparib.
Conclusions: Together, our results demonstrate the potential utility of rapid drug screening combined with genomic
profiling for precision treatment of gynecologic cancers.
- Appears in Collections:
- KIST Publication > Article
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.