Development and Therapeutic Potential of NUAKs Inhibitors
- Development and Therapeutic Potential of NUAKs Inhibitors
- 유경호; 이소하; 노은주; 무하마드 파이잘; 김재호; 홍순선
- NUAK1; NUAK2; ARK5; SNARK; Cancer; Inhibitors
- Issue Date
- Journal of medicinal chemistry
- VOL 64, NO 1-25
- NUAK isoforms, NUAK1 (ARK5) and NUAK2 (SNARK), are important members of the AMPK family of protein kinases. They are involved in a broad spectrum of physiological and cellular events, and sometimes their biological roles overlap. NUAK isoform dysregulation is associated with numerous pathological disorders, including neurodegeneration, metastatic cancer, and diabetes. Therefore, they are promising therapeutic targets in metabolic diseases and cancers; consequently, various NUAK-targeted inhibitors have been disclosed. The first part of this review comprises a brief discussion of the homology, expression, structure, and characteristics of NUAK isoforms. The second part focuses on NUAK isoforms’ involvement in crucial biological operations, including mechanistic findings, highlighting how their abnormal functioning contributes to disease progression and quality of life. The third part summarizes the key findings and applications of targeting NUAK isoforms for treating multiple cancers and neurodegenerative disorders. The final part systematically presents a critical review and analysis of the literature on NUAK isoform inhibitions through small molecules.
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