Anti-adipogenic polyacetylene glycosides from the florets of safflower (carthamus tinctorius)
- Anti-adipogenic polyacetylene glycosides from the florets of safflower (carthamus tinctorius)
- 김진철; 백수철; 이상아; 이범수; 유재식; 방창현; 장태수; 이재철; 김기현
- Issue Date
- VOL 9, NO 91, 91
- Safflower (Carthamus tinctorius) is an annual herb belonging to the Compositae family; it has a history of use as a food colorant, dye, and medicine in oriental countries. LC-MS-UV-based chemical analysis of extract of the florets of C. tinctorius led to the isolation of two new C10-polyacetylene glycosides, (8Z)-decaene-4,6-diyne-1,10-diol-1-O-β-D-glucopyranoside (1) and (8S)-deca-4,6-diyne1,8-diol-1-O-β-D-glucopyranoside (2), together with five known analogs (3？7). The structures of the new compounds were determined by using 1D and 2D NMR spectroscopic data and HR-MS data, as well as chemical transformations. Of compounds 1？7, compounds 2, 3, and 4 inhibited the adipogenesis of 3T3-L1 preadipocytes, whereas compounds 1 and 6 promoted adipogenesis. Compounds 2, 3, and 4 also prevented lipid accumulation through the suppression of the expression of lipogenic genes and the increase of the expression of lipolytic genes. Moreover, compounds 3 and 4 activated AMPK, which is known to facilitate lipid metabolism. Our findings provide a mechanistic rationale for the use of safflower-derived polyacetylene glycosides as potential therapeutic agents against obesity
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