Synthesis of donor/acceptor-substituted diazo compounds in flow and their application in enantioselective dirhodium-catalyzed cyclopropanation and C?H functionalization
- Title
- Synthesis of donor/acceptor-substituted diazo compounds in flow and their application in enantioselective dirhodium-catalyzed cyclopropanation and C?H functionalization
- Authors
- 유천재; Daniel Rackl; Christopher W. Jones; Huw M. L. Davies
- Issue Date
- 2017-06
- Publisher
- Organic letters
- Citation
- VOL 19, NO 12-3058
- Abstract
- A tandem reaction system has been developed for the preparation of donor/acceptor-substituted diazo compounds in continuous flow coupled to dirhodiumcatalyzed C?H functionalization or cyclopropanation. Hydrazones were oxidized in flow by solid-supported N-iodo-ptoluenesulfonamide potassium salt (PS-SO2NIK) to generate the diazo compounds, which were then purified by passing through a column of molecular sieves/sodium thiosulfate.
- URI
- https://pubs.kist.re.kr/handle/201004/72784
- ISSN
- 1523-7060
- Appears in Collections:
- KIST Publication > Article
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