An ImmobilizedDirhodium HollowFiber Flow Reactor for Scalable and Sustainable C？ H Functionalization in Continuous Flow
- An ImmobilizedDirhodium HollowFiber Flow Reactor for Scalable and Sustainable C？ H Functionalization in Continuous Flow
- 유천재; Daniel Rackl; Wenbin Liu; Caroline B. Hoyt; Brian Pimentel; Ryan P. Lively; Huw M. L. Davies; Christopher W. Jones
- Issue Date
- Angewandte Chemie international edition
- VOL 57, NO 34-10927
- A scalable flow reactor is demonstrated for enantioselective and regioselective rhodium carbene reactions (cyclopropanation and C@H functionalization) by developing cascade reaction methods employing a microfluidic flow reactor system containing immobilized dirhodium catalysts in conjunction with the flow synthesis of diazo compounds. This
allows the utilization of the energetic diazo compounds in a safe manner and the recycling of the dirhodium catalysts multiple times. This approach is amenable to application in a bulk-scale synthesis employing asymmetric C@H functionalization by stacking multiple fibers in one reactor module. The products from this sequential flow？flow reactor are compared with a conventional batch reactor or flow？batch reactor in terms of yield, regioselectivity, and enantioselectivity.
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