Ionic contrast across a lipid membrane for Debye length extension: towards an ultimate bioelectronic transducer
- Ionic contrast across a lipid membrane for Debye length extension: towards an ultimate bioelectronic transducer
- 이석; 이관희; 김재헌; 이택진; 김철기; 유용상; 송현석; 이동근; 유의상; 정우혁; 이수호; 한상국; 최명철; 안동준
- bioelectronic transducer; lipid membrane; Debye length; molecular detection
- Issue Date
- Nature Communications
- VOL 12, 3741
- Despite technological advances in biomolecule detections, evaluation of molecular interactions via potentiometric devices under ion-enriched solutions has remained a long-standing problem. To avoid severe performance degradation of bioelectronics by ionic screening effects, we cover probe surfaces of field effect transistors with a single film of the supported lipid bilayer, and realize respectable potentiometric signals from receptor？ligand bindings irrespective of ionic strength of bulky solutions by placing an ion-free water layer underneath the supported lipid bilayer. High-energy X-ray reflectometry together with the circuit analysis and molecular dynamics simulation discovered biochemical findings that effective electrical signals dominantly originated from the sub-nanoscale conformational change of lipids in the course of receptor？ligand bindings. Beyond thorough analysis on the underlying mechanism at the molecular level, the proposed supported lipid bilayer-field effect transistor platform ensures the world-record level of sensitivity in molecular detection with excellent reproducibility regardless of molecular charges and environmental ionic conditions.
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