Label-Free Detection and Discrimination of SARS-CoV-2 Variants Using Terahertz Metamaterial Sensing Platform

Abstract

We present the first label-free detection and discrimination of SARS-CoV-2 variants having global spread (Wild-type, delta and omicron) by combining terahertz (THz) time-domain spectroscopy and a metamaterial-based sensing chip. THz spectra suggest sensitive discrimination between variants that have only one or two different amino-acid sequences for each virus type, respectively, within just few minutes.