Model System for Brain Doping: Identification of the Correlation between Performance Enhancing and Alterations of Neurochemical Profiling

Abstract

Brain doping which stimulates specific brain region to increase sport performance, has been reported consistently, but there is no definite provision or detection method to deal with it. We have made the following plans to establish the brain doping diagnosis system. 1) Develop a brain doping model system that transmits stimuli using transcranial direct current stimulation (tDCS) equipment. 2) To investigate neurotransmitters mediating brain doping signals, urine samples obtained through a model system are analyzed with neurotransmitters analysis method. 3) Select the markers of brain doping by observing a comprehensive method. We developed a model system of brain doping using rats and conducted a preliminary experiment. The stimulus was delivered using the pattern of neurotransmitters and establish the brain doping diagnosis DCS to the rat brain, and the performance enhancing before and after the stimulus were compared through three independent behavioral testing: endurance, balance, and muscle strength. At the same time, urine was collected to determine the correlation between motor capacity and neurotransmitters through the neurotransmitter detection method developed in the previous year. Preliminary experiments with the model system showed some improvement in endurance and balance, and neurotransmitters showed different pattern of before and after stimulation. Based on this results, deep study observing the changes in the motor performance according to the stimulus site and intensity, and grasping the alteration of the pattern of neurotransmitters in more detail are in progress. In conclusion, we will discover core multiple biomarkers of brain doping and suggest the direction of the diagnosis method detecting brain doping.