Browsing by Author Nathanael S. Gray

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Showing results 1 to 30 of 48

Issue DateTitleAuthor(s)
2017-01A benzo[b]thiophene-based selective type 4 S1P receptor agonistNathanael S. Gray; 허우영; Hugh Rosen
2014-11A Discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding RegionJamie A. Moroco; Matthew P. Baumgartner; Heather L. Rust; Hwan Geun Choi; 허우영; Nathanael S. Gray; Carlos J. Camacho; Thomas E. Smithgall
2010-05A Small-Molecule Inducer of the Antioxidant Response Element허우영; Zheng Sun; Tao Jiang; Daniel E. Mason; Eric C. Peters; Donna D. Zhang; Hendrik Luesch; Peter G. Schultz; Nathanael S. Gray
2010-03A Structure-Guided Approach to Creating Covalent FGFR InhibitorsWenjun Zhou; 허우영; Ultan McDermott; Amit Dutt; Wa Xian; Scott B. Ficarro; Jianming Zhang; Sreenath V. Sharma; Joan Brugge; Matthew Meyerson; Jeffrey Settleman; Nathanael S. Gray
2010-08A Type-II Kinase Inhibitor Capable of Inhibiting the T315I “Gatekeeper” Mutant of Bcr-Abl최환근; Pingda Ren; Francisco Adrian; Fangxian Sun; Hyun Soo Lee; Xia Wang; Qiang Ding; Guobao Zhang; Yongping Xie; Jianming Zhang; Yi Liu; Tove Tuntland; Markus Warmuth; Paul W. Manley; Jrgen Mestan; Nathanael S. Gray; 심태보
2010-07Broad spectrum alkynyl inhibitors of T315I Bcr-Abl임상민; Xianming Deng; Jianming Zhang; Nathanael S. Gray
2017-09Characterization of a highly selective inhibitor of the Aurora kinases심태보; Fleur M. Ferguson; Zainab M. Doctor; Apirat Chaikuad; Nam Doo Kim; Stefan Knapp; Nathanael S. Gray
2013-04Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATRQingsong Liu; Chunxiao Xu; Sivapriya Kirubakaran; Xin Zhang; 허우영; Yan Liu; Nicholas P. Kwiatkowski; Jinhua Wang; Kenneth D. Westover; Peng Gao; Dalia Ercan; Mario Niepel; Carson C. Thoreen; Seong A. Kang; Matthew P. Patricelli; Yuchuan Wang; Tanya Tupper; Abigail Altabef; Hidemasa Kawamura; Kathryn D. Held; Danny M. Chou; Stephen J. Elledge; Pasi A. Janne; Kwok-Kin Wong; David M. Sabatini; Nathanael S. Gray
2008-07Clinical stage EGFR inhibitors irreversibly alkylate Bmx kinase허우영; Anastasia Velentza; Sungjoon Kim; Laura Flatauer; Xinnong Jiang; David Valente; Daniel E. Mason; Melissa Suzuki; Brad Larson; Jianming Zhang; Anna Zagorska; Michael DiDonato; Advait Nagle; Markus Warmuth; Steven P. Balk; Eric C. Peters; Nathanael S. Gray
2017-01Covalent Guanosine Mimetic Inhibitors of G12C KRAS심태보; 임상민; Yuan Xiong; Jia Lu; John Hunter; Lianbo Li; David Scott; 최환근; Anju Manandhar; Sudershan Gondi; Kenneth D. Westover; Nathanael S. Gray
2012-09Development of ATP-Competitive mTOR Inhibitors허우영; Qingsong Liu; Seong A. Kang; Carson C. Thoreen; Jinhua Wang; Jae Won Chang; Andrew Markhard; Jianming Zhang; Taebo Sim; David M. Sabatini; Nathanael S. Gray
2016-08Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo심태보; Thomas B. Sundberg; Yanke Liang; Huixian Wu; Hwan Geun Choi; Nam Doo Kim; Liv Johannessen; Adam Petrone; Bernard Khor; Daniel B. Graham; Isabel J. Latorre; Andrew J. Phillips; Stuart L. Schreiber; Jose Perez; Alykhan F. Shamji; Nathanael S. Gray; Ramnik J. Xavier
2014-11Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitorsLi Tan; Jun Wang; Junko Tanizaki; Zhifeng Huang; Amir R. Aref; Maria Rusan; Su-Jie Zhu; Yiyun Zhang; Dalia Ercan; Rachel G. Liao; Marzia Capelletti; Wenjun Zhou; 허우영; NamDoo Kim; 심태보; Suzanne Gaudet; David A. Barbie; Jing-Ruey Joanna Yeh; Cai-Hong Yun; Peter S. Hammerman; Moosa Mohammadi; Pasi A. Janne; Nathanael S. Gray
2018-06Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8심태보; John M. Hatcher; Eric S. Wang; Liv Johannessen; Nicholas Kwiatkowski; Nathanael S. Gray
2015-08Development of Small Molecules Targeting the Pseudokinase Her3심태보; 임상민; Ting Xie; Kenneth D. Westover; Scott. B. Ficarro; 태현섭; Deepak Gurbani; Jarrod A. Marto; Pasi A. Janne; Craig M. Crews; Nathanael S. Gray
2012-08Development of ‘DFG-out’ inhibitors of gatekeeper mutant kinases최환근; Jianming Zhang; Ellen Weisberg; James D. Griffin; 심태보; Nathanael S. Gray
2011-05Discovery and optimization of potent and selective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse microsome stabilityQingsong Liu; Jinhua Wang; Seong A. Kang; Carson C. Thoreen; 허우영; Hwan Geun Choi; David L. Waller; Taebo Sim; David M. Sabatini; Nathanael S. Gray
2010-09Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective Mammalian Target of Rapamycin (mTOR) Inhibitor for the Treatment of CancerQingsong Liu; Jae Won Chang; Jinhua Wang; Seong A. Kang; Carson C. Thoreen; Andrew Markhard; 허우영; Jianming Zhang; Taebo Sim; David M. Sabatini; Nathanael S. Gray
2011-02Discovery of 9-(6-Aminopyridin-3-yl)-1-(3-(trifluoromethyl)-phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a Potent, Selective, and Orally Available Mammalian Target of Rapamycin (mTOR) Inhibitor for Treatment of CancerQingsong Liu; Jinhua Wang; Seong A. Kang; Carson C. Thoreen; 허우영; Tausif Ahmed; David M. Sabatini; Nathanael S. Gray
2016-05Discovery of a Highly Potent and Selective Indenoindolone Type 1 Pan-FLT3 Inhibitor심태보; John M. Hatcher; Ellen Weisberg; Richard M. Stone; Suiyang Liu; James D. Griffin; Nathanael S. Gray
2013-04Discovery of a Selective Irreversible BMX Inhibitor for Prostate CancerFeiyang Liu; Xin Zhang; Ellen Weisberg; Sen Chen; 허우영; Hong Wu; Zheng Zhao; Wenchao Wang; Mao Mao; Changmeng Cai; Nicholas I. Simon; Takaomi Sanda; Jinhua Wang; A. Thomas Look; James D. Griffin; Steven P. Balk; Qingsong Liu; Nathanael S. Gray
2016-10Discovery of a Series of 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-ones as Selective PI3K-delta/gamma Inhibitors심태보; Fleur M. Ferguson; Jing Ni; Tinghu Zhang; Bethany Tesar; 김남두; Xianming Deng; Jennifer R. Brown; Jean J. Zhao; Nathanael S. Gray
2015-12Discovery of Inhibitors That Overcome the G1202R Anaplastic Lymphoma Kinase Resistance MutationJohn M. Hatcher; Magda Bahcall; Hwan Geun Choi; Yang Gao; 심태보; Rani George; Pasi A. Janne; Nathanael S. Gray
2012-01Discovery of Potent and Selective Covalent Inhibitors of JNKTinghu Zhang; Francisco Inesta-Vaquera; Mario Niepel; Jianming Zhang; Scott B. Ficarro; Thomas Machleidt; Ting Xie; Jarrod A. Marto; NamDoo Kim; 심태보; John D. Laughlin; Hajeung Park; Philip V. LoGrasso; Matt Patricelli; Tyzoon K. Nomanbhoy; Peter K. Sorger; Dario R. Alessi; Nathanael S. Gray
2009-12Discovery of pyrimidine benzimidazoles as Src-family selective Lck inhibitorsGuobao Zhang; Pingda Ren; Nathanael S. Gray; 심태보; Xia Wang; Yi Liu; Jianwei Che; Weitong Dong; Shin-Shay Tian; Mark L. Sandberg; Tracy A. Spalding; Russell Romeo; Maya Iskandar; Zhiliang Wang; Martin Seidel; Donald S. Karanewsky; Yun He
2015-01Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2)Li Tan; Tyzoon Nomanbhoy; Deepak Gurbani; Matthew Patricelli; John Hunter; Jiefei Geng; Lina Herhaus; Jianming Zhang; Eduardo Pauls; Youngjin Ham; Hwan Geun Choi; Ting Xie; Xianming Deng; Sara J. Buhrlage; 심태보; Philip Cohen; Gopal Sapkota; Kenneth D. Westover; Nathanael S. Gray
2010-10Expanding the Diversity of Allosteric Bcr-Abl InhibitorsXianming Deng; Barun Okram; Qiang Ding; Jianming Zhang; Yongmun Choi; Francisco J. Adrin; Amy Wojciechowski; Guobao Zhang; Jianwei Che; Badry Bursulaya; Sandra W. Cowan-Jaco; Gabriele Rummel; 심태보; Nathanael S. Gray
1998-07Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitorsNathanael S. Gray; Lisa Wodicka; Andy-Mark W. H. Thunnissen; Thea C. Norman; Soojin Kwon; F. Hernan Espinoza; David O. Morgan; Georjana Barnes; Sophie LeClerc; Laurent Meijer; 김성호; David J. Lockhart; Peter G. Schultz
2018-09First SAR Study for Overriding NRAS Mutant Driven Acute Myeloid심태보; 허우영; 최승혜; 조한나; 신인재; Eunhye Ju; Haelee Kim; Eunmi Hong; Nam Doo Kim; Hwan Geun Choi; Nathanael S. Gray
2017-01Identification of Existing Drugs That Effectively Target NTRK1 and ROS1 Rearrangements in Lung Cancer심태보; Curtis R. Chong; Magda Bahcall; Takayuki Kosaka; Dalia Ercan; Lynette M. Sholl; Mizuki Nishino; Bruce E. Johnson; Nathanael S. Gray; Pasi A. Janne; Marzia Capelletti

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