Showing results 1 to 14 of 14
Issue Date | Title | Author(s) |
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2017-06-15 | Design, synthesis, biological evaluation and molecular modelling of 2-(2-aryloxyphenyl)-1,4-dihydroisoquinolin-3(2H)-ones: A novel class of TSPO ligands modulating amyloid-beta-induced mPTP opening | Elkamhawy, Ahmed; Park, Jung-eun; Hassan, Ahmed H. E.; Pae, Ae Nim; Lee, Jiyoun; Park, Beoung-Geon; Paik, Sora; Do, Jimin; Park, Jong-Hyun; Park, Ki Duk; Moon, Bongjin; Park, Woo Kyu; Cho, Heeyeong; Jeong, Dae Young; Roh, Eun Joo |
2021-11 | Discovery of 3,4-dichloro-N-(1H-indol-5-yl)benzamide: A highly potent, selective, and competitive hMAO-B inhibitor with high BBB permeability and action | Elkamhawy, Ahmed; Kim, Hyeon Jeong; Elsherbeny, Mohamed H.; Paik, Sora; Park, Jong-Hyun; Gotina, Lizaveta; Abdellattif, Magda H.; Gouda, Noha A.; Cho, Jungsook; Lee, Kyeong; Pae, Ae Nim; Park, Ki Duk; Roh, Eun Joo |
2020-01 | Discovery of N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B | Elkamhawy, Ahmed; Paik, Sora; Kim, Hyeon Jeong; Park, Jong-Hyun; Londhe, Ashwini M.; Lee, Kyeong; Pae, Ae Nim; Park, Ki Duk; Roh, Eun Joo |
2019-05 | EGFR inhibitors from cancer to inflammation: Discovery of 4-fluoro-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide as a novel anti-inflammatory EGFR inhibitor | Elkamhawy, Ahmed; Hassan, Ahmed H. E.; Paik, Sora; Lee, Yong Sup; Lee, Hwi-Ho; Shin, Ji-Sun; Lee, Kyung-Tae; Roh, Eun Joo |
2017-11 | Hit discovery of 4-amino-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide: A novel EGFR inhibitor from a designed small library | Elkamhawy, Ahmed; Paik, Sora; Hassan, Ahmed H. E.; Lee, Yong Sup; Roh, Eun Joo |
2022-09 | Identification of Novel Aryl Carboxamide Derivatives as Death-Associated Protein Kinase 1 (DAPK1) Inhibitors with Anti-Proliferative Activities: Design, Synthesis, In Vitro, and In Silico Biological Studies | Elkamhawy, Ahmed; Paik, Sora; Ali, Eslam M. H.; Hassan, Ahmed H. E.; Kang, So Jin; Lee, Kyeong; Roh, Eun Joo |
2019-11 | Optimization study towards more potent thiazolidine-2,4-dione IKK-beta modulator: Synthesis, biological evaluation and in silico docking simulation | Elkamhawy, Ahmed; Kim, Nam Youn; Hassan, Ahmed H. E.; Park, Jung-eun; Yang, Jeong-Eun; Elsherbeny, Mohamed H.; Paik, Sora; Oh, Kwang-Seok; Lee, Byung Ho; Lee, Mi Young; Shin, Kye Jung; Pae, Ae Nim; Lee, Kyung-Tae; Roh, Eun Joo |
2018-09-05 | Pyrazinyl ureas revisited: 1-(3-(Benzyloxy)pyrazin-2-yl)-3-(3,4-dichlorophenyl)urea, a new blocker of A beta-induced mPTP opening for Alzheimer's disease | Elkamhawy, Ahmed; Park, Jung-eun; Hassan, Ahmed H. E.; Pae, Ae Nim; Lee, Jiyoun; Paik, Sora; Park, Beoung-Geon; Roh, Eun Joo |
2018-05-10 | Repositioning of the antipsychotic trifluoperazine: Synthesis, biological evaluation and in silico study of trifluoperazine analogs as anti-glioblastoma agents | Kang, Seokmin; Lee, Jung Moo; Jeon, Borami; Elkamhawy, Ahmed; Paik, Sora; Hong, Jinpyo; Oh, Soo-Jin; Paek, Sun Ha; Lee, C. Justin; Hassan, Ahmed H. E.; Kang, Sang Soo; Roh, Eun Joo |
2021-09 | Scaffold Repurposing of In-House Small Molecule Candidates Leads to Discovery of First-in-Class CDK-1/HER-2 Dual Inhibitors: In Vitro and In Silico Screening | Elkamhawy, Ahmed; Ammar, Usama M.; Paik, Sora; Abdellattif, Magda H.; Elsherbeny, Mohamed H.; Lee, Kyeong; Roh, Eun Joo |
2020-07 | Sulfonamide-based 4-anilinoquinoline derivatives as novel dual Aurora kinase (AURKA/B) inhibitors: Synthesis, biological evaluation and in silico insights | Al-Sanea, Mohammad M.; Elkamhawy, Ahmed; Paik, Sora; Lee, Kyeong; El Kerdawy, Ahmed M.; Abbas, Bukhari Syed Nasir; Roh, Eun Joo; Eldehna, Wagdy M.; Elshemy, Heba A. H.; Bakr, Rania B.; Farahat, Ibrahim Ali; Alzarea, Abdulaziz, I; Alzarea, Sami, I; Alharbi, Khalid S.; Abdelgawad, Mohamed A. |
2019-01-01 | Synthesis and biological evaluation of novel 3-(quinolin-4-ylamino)benzenesulfonamidesAQ3 as carbonic anhydrase isoforms I and II inhibitors | Al-Sanea, Mohammad M.; Elkamhawy, Ahmed; Paik, Sora; Bua, Silvia; Lee, So Ha; Abdelgawad, Mohamed A.; Roh, Eun Joo; Eldehna, Wagdy M.; Supuran, Claudiu T. |
2017-12-01 | Synthesis and evaluation of new pyridyl/pyrazinyl thiourea derivatives: Neuroprotection against amyloid-beta-induced toxicity | Park, Jung-eun; Elkamhawy, Ahmed; Hassan, Ahmed H. E.; Pae, Ae Nim; Lee, Jiyoun; Paik, Sora; Park, Beoung-Geon; Roh, Eun Joo |
2020-02-15 | Thiazolidine-2,4-dione-based irreversible allosteric IKK-beta kinase inhibitors: Optimization into in vivo active anti-inflammatory agents | Elkamhawy, Ahmed; Kim, Nam Youn; Hassan, Ahmed H. E.; Park, Jung-eun; Paik, Sora; Yang, Jeong-Eun; Oh, Kwang-Seok; Lee, Byung Ho; Lee, Mi Young; Shin, Kye Jung; Pae, Ae Nim; Lee, Kyung-Tae; Roh, Eun Joo |