Browsing byAuthorRoh, Eun Joo

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Showing results 1 to 30 of 65

Issue DateTitleAuthor(s)
2022-062-(3-Bromophenyl)-8-fluoroquinazoline-4-carboxylic Acid as a Novel and Selective Aurora A Kinase Inhibitory Lead with Apoptosis Properties: Design, Synthesis, In Vitro and In Silico Biological EvaluationElsherbeny, Mohamed H.; Ammar, Usama M.; Abdellattif, Magda H.; Abourehab, Mohammed A. S.; Abdeen, Ahmed; Ibrahim, Samah F.; Abdelrahaman, Doaa; Mady, Wessam; Roh, Eun Joo; Elkamhawy, Ahmed
2022-07AF8c, a Multi-Kinase Inhibitor Induces Apoptosis by Activating DR5/Nrf2 via ROS in Colorectal Cancer CellsJeong, Soyeon; Farag, Ahmed K.; Yun, Hye Kyeong; Jeong, Yoon A.; Kim, Dae Yeong; Jo, Min Jee; Park, Seong Hye; Kim, Bo Ram; Kim, Jung Lim; Kim, Bu Gyeom; Lee, Dae-Hee; Roh, Eun Joo; Oh, Sang Cheul
2019-10AF8c, a pan-ErbB family inhibitor induces apoptotic cell death by stimulating DR5/Nrf2 via ROS in colorectal cancer cellsJeong, Soyeon; Farag, Ahmed Karam; Yun, Hye Kyeong; Jeong, Yoon A.; Kim, Dae Yeong; Jo, Min Jee; Park, Seong Hye; Kim, Bo Ram; Kim, Jung Lim; Lee, Dae-Hee; Roh, Eun Joo; Oh, Sang Cheul
2010-02-01Caffeine-Mediated Inhibition of Calcium Release Channel Inositol 1,4,5-Trisphosphate Receptor Subtype 3 Blocks Glioblastoma Invasion and Extends SurvivalKang, Sang Soo; Han, Kyung-Seok; Ku, Bo Mi; Lee, Yeon Kyung; Hong, Jinpyo; Shin, Hye Young; Almonte, Antoine G.; Woo, Dong Ho; Brat, Daniel J.; Hwang, Eun Mi; Yoo, Seung Hyun; Chung, Chun Kee; Park, Sung-Hye; Paek, Sun Ha; Roh, Eun Joo; Lee, Sung Joong; Park, Jae-Yong; Traynelis, Stephen F.; Lee, C. Justin
2019-01Death-associated protein kinase (DAPK) family modulators: Current and future therapeutic outcomesFarag, Ahmed Karam; Roh, Eun Joo
2015-07Design and Synthesis of New [1,2,3]Triazolo[4,5-d]pyrimidine Derivatives as Potential Antiproliferative AgentsElkamhawy, Ahmed; Al-Sanea, Mohammad M.; Song, Chiman; Sim, Taebo; Roh, Eun Joo
2022-07Design, Synthesis and Biological Evaluation of 1,3,5-Triazine Derivatives Targeting hA(1) and hA(3) Adenosine ReceptorPark, Sujin; Ahn, Yujin; Kim, Yongchan; Roh, Eun Joo; Lee, Yoonji; Han, Chaebin; Yoo, Hee Min; Yu, Jinha
2018-09-05Design, synthesis and biological evaluation of novel thiazolidinedione derivatives as irreversible allosteric IKK-beta modulatorsElkamhawy, Ahmed; Kim, Nam Youn; Hassan, Ahmed H. E.; Park, Jung-eun; Yang, Jeong-Eun; Oh, Kwang-Seok; Lee, Byung Ho; Lee, Mi Young; Shin, Kye Jung; Lee, Kyung-Tae; Hur, Wooyoung; Roh, Eun Joo
2018-12-15Design, synthesis, and biological evaluation of novel aminopyrimidinylisoindolines as AXL kinase inhibitorsChoi, Min Jung; Roh, Eun Joo; Hur, Wooyoung; Lee, So Ha; Sim, Taebo; Oh, Chang-Hyun; Lee, Sun-Hwa; Kim, Jong Seung; Yoo, Kyung Ho
2022-09Design, synthesis, and biological evaluation of pseudo-bicyclic pyrimidine-based compounds as potential EGFR inhibitorsFarag, Ahmed Karam; Ahn, Byung Sun; Yoo, Je Sik; Karam, Reham; Roh, Eun Joo
2017-06-15Design, synthesis, biological evaluation and molecular modelling of 2-(2-aryloxyphenyl)-1,4-dihydroisoquinolin-3(2H)-ones: A novel class of TSPO ligands modulating amyloid-beta-induced mPTP openingElkamhawy, Ahmed; Park, Jung-eun; Hassan, Ahmed H. E.; Pae, Ae Nim; Lee, Jiyoun; Park, Beoung-Geon; Paik, Sora; Do, Jimin; Park, Jong-Hyun; Park, Ki Duk; Moon, Bongjin; Park, Woo Kyu; Cho, Heeyeong; Jeong, Dae Young; Roh, Eun Joo
2014-05-03Determination of Edible Vegetable Oil Adulterants in Sesame Oil Using H-1 Nuclear Magnetic Resonance SpectroscopyNam, Yun Sik; Noh, Kown-Chul; Roh, Eun Joo; Keum, Gyochang; Lee, Yeonhee; Lee, Kang-Bong
2021-01-14Development and Therapeutic Potential of NUAKs InhibitorsFaisal, Muhammad; Kim, Jae Ho; Yoo, Kyung Ho; Roh, Eun Joo; Hong, Soon Sun; Lee, So Ha
2021-09Development of New Meridianin/Leucettine-Derived Hybrid Small Molecules as Nanomolar Multi-Kinase Inhibitors with Antitumor ActivityElsherbeny, Mohamed H.; Elkamhawy, Ahmed; Nada, Hossam; Abdellattif, Magda H.; Lee, Kyeong; Roh, Eun Joo
2008-10Development of selective blockers for Ca2+-activated Cl- channel using Xenopus laevis oocytes with an improved drug screening strategyOh, Soo-Jin; Park, Jung Hwan; Han, Sungyu; Lee, Jae Kyun; Roh, Eun Joo; Lee, C. Justin
2023-12Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatmentsAntar, Samar A.; Ashour, Nada A.; Sharaky, Marwa; Khattab, Muhammad; Ashour, Naira A.; Zaid, Roaa T.; Roh, Eun Joo; Elkamhawy, Ahmed; Al-Karmalawy, Ahmed A.
2020-10Diarylurea derivatives comprising 2,4-diarylpyrimidines: Discovery of novel potential anticancer agents via combined failed-ligands repurposing and molecular hybridization approachesFarag, Ahmed Karam; Hassan, Ahmed H. E.; Chung, Kyung-Sook; Lee, Jeong-Hun; Gil, Hyo-Sun; Lee, Kyung-Tae; Roh, Eun Joo
2017-03-10Discovery of 1-(3-(benzyloxy)pyridin-2-yl)-3-(2-(piperazin-1-yl)ethyl)urea: A new modulator for amyloid beta-induced mitochondrial dysfunctionElkamhawy, Ahmed; Park, Jung-Eun; Hassan, Ahmed H. E.; Ra, Hyunhwa; Pae, Ae Nim; Lee, Jiyoun; Park, Beoung-Geon; Moon, Bongjin; Park, Hyun-Mee; Roh, Eun Joo
2021-11Discovery of 3,4-dichloro-N-(1H-indol-5-yl)benzamide: A highly potent, selective, and competitive hMAO-B inhibitor with high BBB permeability and actionElkamhawy, Ahmed; Kim, Hyeon Jeong; Elsherbeny, Mohamed H.; Paik, Sora; Park, Jong-Hyun; Gotina, Lizaveta; Abdellattif, Magda H.; Gouda, Noha A.; Cho, Jungsook; Lee, Kyeong; Pae, Ae Nim; Park, Ki Duk; Roh, Eun Joo
2016-01-02Discovery of a broad spectrum antiproliferative agent with selectivity for DDR1 kinase: cell line-based assay, kinase panel, molecular docking, and toxicity studiesElkamhawy, Ahmed; Park, Jung-eun; Cho, Nam-Chul; Sim, Taebo; Pae, Ae Nim; Roh, Eun Joo
2020-01Discovery of N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase BElkamhawy, Ahmed; Paik, Sora; Kim, Hyeon Jeong; Park, Jong-Hyun; Londhe, Ashwini M.; Lee, Kyeong; Pae, Ae Nim; Park, Ki Duk; Roh, Eun Joo
2011-05-15Discovery of piperidinyl aminopyrimidine derivatives as IKK-2 inhibitorsKim, Sora; Jung, Jin Kyo; Lee, Hyo Seon; Kim, Youngjae; Kim, Jiyoon; Choi, Kihang; Baek, Du-Jong; Moon, Bongjin; Oh, Kwang-Seok; Lee, Byung Ho; Shin, Kye Jung; Pae, Ae Nim; Nam, Ghilsoo; Roh, Eun Joo; Cho, Yong Seo; Choo, Hyunah
2015-10-20Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme (GBM)Elkamhawy, Ahmed; Viswanath, Ambily Nath Indu; Pae, Ae Nim; Kim, Hyeon Young; Heo, Jin-Chul; Park, Woo-Kyu; Lee, Chong-Ock; Yang, Heekyoung; Kim, Kang Ho; Nam, Do-Hyun; Seol, Ho Jun; Cho, Heeyeong; Roh, Eun Joo
2012-09-01Discovery of potent and selective rhodanine type IKK beta inhibitors by hit-to-lead strategySong, Hyeseung; Lee, Yun Suk; Roh, Eun Joo; Seo, Jae Hong; Oh, Kwang-Seok; Lee, Byung Ho; Han, Hogyu; Shin, Kye Jung
2019-05EGFR inhibitors from cancer to inflammation: Discovery of 4-fluoro-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide as a novel anti-inflammatory EGFR inhibitorElkamhawy, Ahmed; Hassan, Ahmed H. E.; Paik, Sora; Lee, Yong Sup; Lee, Hwi-Ho; Shin, Ji-Sun; Lee, Kyung-Tae; Roh, Eun Joo
2019-01-15First-in-class DAPK1/CSF1R dual inhibitors: Discovery of 3,5-dimethoxy-N-(4-(4-methoxyphenoxy)-24(6-morpholinopyridin-3-yl)amino) pyrimidin-5-yl)benzamide as a potential anti-tauopathies agentFarag, Ahmed Karam; Hassan, Ahmed H. E.; Jeong, Hyeanjeong; Kwon, Youngji; Choi, Jin Gyu; Oh, Myung Sook; Park, Ki Duk; Kim, Yun Kyung; Roh, Eun Joo
2008-05Functional human 5-HT6 receptor assay for high throughput screening of chemical ligands and binding proteinsKim, Hyun-Ji; Yun, Hyung-Mun; Kim, Taehyun; Nam, Ghilsoo; Roh, Eun Joo; Kostenis, Evi; Choo, Hea-Young Park; Pae, Ae Nim; Rhim, Hyewhon
2017-11Hit discovery of 4-amino-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide: A novel EGFR inhibitor from a designed small libraryElkamhawy, Ahmed; Paik, Sora; Hassan, Ahmed H. E.; Lee, Yong Sup; Roh, Eun Joo
2022-09Identification of Novel Aryl Carboxamide Derivatives as Death-Associated Protein Kinase 1 (DAPK1) Inhibitors with Anti-Proliferative Activities: Design, Synthesis, In Vitro, and In Silico Biological StudiesElkamhawy, Ahmed; Paik, Sora; Ali, Eslam M. H.; Hassan, Ahmed H. E.; Kang, So Jin; Lee, Kyeong; Roh, Eun Joo
2024-01Integrating computational methods guided the discovery of phytochemicals as potential Pin1 inhibitors for cancer: pharmacophore modeling, molecular docking, MM-GBSA calculations and molecular dynamics studiesAlzain, Abdulrahim A.; Elbadwi, Fatima A.; Shoaib, Tagyedeen H.; Sherif, Asmaa E.; Osman, Wadah; Ashour, Ahmed; Mohamed, Gamal A.; Ibrahim, Sabrin R. M.; Roh, Eun Joo; Hassan, Ahmed H. E.

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