Catechol/aldehyde Moiety-based Bioadhesive ThermosensitivePoly(organophosphazenes) Hydrogel System

Abstract

Injectable tissue adhesives using catechol have been raised as problems such as reduced effectiveness, dispersion into surrounding tissues and toxicity due to catechol groups. To overcome these problems, we designed that a thermo-sensitive and adhesive hydrogel with special characteristics, 1) rapid gelation to reduce the dispersion of the adhesive within body, 2) temperature-dependent hydrogel network formation to improve the adhesive effect by increased the number of cohesive networks and tissue-adhesive catechol moieties due to replacement of cohesive networks between catechol moieties, and 3) reduction the toxicity by catechol group. Here, the adhesive hydrogel system was developed by mixing the synthesized polymers. The structure of the polymer complex was analyzed using 1H nuclear magnetic resonance spectroscopy and Fourier transform infrared spectroscopy. In addition, the sol-gel transition and biocompatibility of the polymer were confirmed. Finally, it was confirmed that the potential of tissue adhesive through the adhesion test on various materials.