Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyesu | - |
dc.contributor.author | Kim, Hyungsup | - |
dc.contributor.author | Cho, Hawon | - |
dc.contributor.author | Lee, Byeongjun | - |
dc.contributor.author | Lu, Huan-Jun | - |
dc.contributor.author | Kim, Kyungmin | - |
dc.contributor.author | Chung, Sooyoung | - |
dc.contributor.author | Shim, Won-Sik | - |
dc.contributor.author | Shin, Young Kee | - |
dc.contributor.author | Dong, Xinzhong | - |
dc.contributor.author | Wood, John N. | - |
dc.contributor.author | Oh, Uhtaek | - |
dc.date.accessioned | 2024-01-19T11:00:22Z | - |
dc.date.available | 2024-01-19T11:00:22Z | - |
dc.date.created | 2022-11-04 | - |
dc.date.issued | 2022-11 | - |
dc.identifier.issn | 0304-3959 | - |
dc.identifier.uri | https://pubs.kist.re.kr/handle/201004/114409 | - |
dc.description.abstract | Itch is an unpleasant sensation that evokes a desire to scratch. Pathologic conditions such as allergy or atopic dermatitis produce severe itching sensation. Mas-related G protein receptors (Mrgprs) are receptors for many endogenous pruritogens. However, signaling pathways downstream to these receptors in dorsal root ganglion (DRG) neurons are not yet understood. We found that anoctamin 1 (ANO1), a Ca2+-activated chloride channel, is a transduction channel mediating Mrgpr-dependent itch signals. Genetic ablation of Ano1 in DRG neurons displayed a significant reduction in scratching behaviors in response to acute and chronic Mrgpr-dependent itch models and the epidermal hyperplasia induced by dry skin. In vivo Ca2+ imaging and electrophysiological recording revealed that chloroquine and other agonists of Mrgprs excited DRG neurons via ANO1. More importantly, the overexpression of Ano1 in DRG neurons of Ano1-deficient mice rescued the impaired itching observed in Ano1-deficient mice. These results demonstrate that ANO1 mediates the Mrgpr-dependent itch signaling in pruriceptors and provides clues to treating pathologic itch syndromes. | - |
dc.language | English | - |
dc.publisher | Elsevier BV | - |
dc.title | Anoctamin 1/TMEM16A in pruritoceptors is essential for Mas-related G protein receptor-dependent itch | - |
dc.type | Article | - |
dc.identifier.doi | 10.1097/j.pain.0000000000002611 | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | Pain, v.163, no.11, pp.2172 - 2184 | - |
dc.citation.title | Pain | - |
dc.citation.volume | 163 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 2172 | - |
dc.citation.endPage | 2184 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.wosid | 000868828900014 | - |
dc.relation.journalWebOfScienceCategory | Anesthesiology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalResearchArea | Anesthesiology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | BEHAVIORAL-RESPONSES | - |
dc.subject.keywordPlus | SENSORY NEURONS | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | DRY SKIN | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | HISTAMINE | - |
dc.subject.keywordPlus | PAIN | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | PRURITUS | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordAuthor | Anoctamin 1 | - |
dc.subject.keywordAuthor | Pruriceptors | - |
dc.subject.keywordAuthor | Itch | - |
dc.subject.keywordAuthor | Mrgprs | - |
dc.subject.keywordAuthor | Bilirubin | - |
dc.subject.keywordAuthor | Chloroquine | - |
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