Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Young-Min | - |
dc.contributor.author | Kim, Min Sun | - |
dc.contributor.author | Jo, Juyeong | - |
dc.contributor.author | Shin, Daiha | - |
dc.contributor.author | Kwon, Seung-Hae | - |
dc.contributor.author | Seo, Jong Bok | - |
dc.contributor.author | Kang, Dongmin | - |
dc.contributor.author | Lee, Byoung Dae | - |
dc.contributor.author | Ryu, Hoon | - |
dc.contributor.author | Hwang, Eun Mi | - |
dc.contributor.author | Kim, Jae-Min | - |
dc.contributor.author | Patel, Paresh D. | - |
dc.contributor.author | Lyons, David M. | - |
dc.contributor.author | Schatzberg, Alan F. | - |
dc.contributor.author | Her, Song | - |
dc.date.accessioned | 2024-01-19T14:01:10Z | - |
dc.date.available | 2024-01-19T14:01:10Z | - |
dc.date.created | 2022-01-10 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 1359-4184 | - |
dc.identifier.uri | https://pubs.kist.re.kr/handle/201004/116513 | - |
dc.description.abstract | The fine-tuning of neuroinflammation is crucial for brain homeostasis as well as its immune response. The transcription factor, nuclear factor-kappa-B (NF kappa B) is a key inflammatory player that is antagonized via anti-inflammatory actions exerted by the glucocorticoid receptor (GR). However, technical limitations have restricted our understanding of how GR is involved in the dynamics of NF kappa B in vivo. In this study, we used an improved lentiviral-based reporter to elucidate the time course of NF kappa B and GR activities during behavioral changes from sickness to depression induced by a systemic lipopolysaccharide challenge. The trajectory of NF kappa B activity established a behavioral basis for the NF kappa B signal transition involved in three phases, sickness-early-phase, normal-middle-phase, and depressive-like-late-phase. The temporal shift in brain GR activity was differentially involved in the transition of NF kappa B signals during the normal and depressive-like phases. The middle-phase GR effectively inhibited NF kappa B in a glucocorticoid-dependent manner, but the late-phase GR had no inhibitory action. Furthermore, we revealed the cryptic role of basal GR activity in the early NF kappa B signal transition, as evidenced by the fact that blocking GR activity with RU486 led to early depressive-like episodes through the emergence of the brain NF kappa B activity. These results highlight the inhibitory action of GR on NF kappa B by the basal and activated hypothalamic-pituitary-adrenal (HPA)-axis during body-to-brain inflammatory spread, providing clues about molecular mechanisms underlying systemic inflammation caused by such as COVID-19 infection, leading to depression. | - |
dc.language | English | - |
dc.publisher | SPRINGERNATURE | - |
dc.title | Decoding the temporal nature of brain GR activity in the NF kappa B signal transition leading to depressive-like behavior | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41380-021-01016-1 | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | MOLECULAR PSYCHIATRY, v.26, no.9, pp.5087 - 5096 | - |
dc.citation.title | MOLECULAR PSYCHIATRY | - |
dc.citation.volume | 26 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 5087 | - |
dc.citation.endPage | 5096 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.wosid | 000610020200006 | - |
dc.identifier.scopusid | 2-s2.0-85099857293 | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.type.docType | Article; Early Access | - |
dc.subject.keywordPlus | PITUITARY-ADRENAL AXIS | - |
dc.subject.keywordPlus | INNATE IMMUNE-SYSTEM | - |
dc.subject.keywordPlus | GLUCOCORTICOID-RECEPTOR | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | HPA | - |
dc.subject.keywordPlus | PATHOPHYSIOLOGY | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | COMPLEXITY | - |
dc.subject.keywordAuthor | NFkB signal | - |
dc.subject.keywordAuthor | glucocorticoid | - |
dc.subject.keywordAuthor | depressive-like behavior | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.