Heracleum dissectum Ledeb. ethanol extract attenuates metabolic syndrome symptoms in high-fat diet-induced obese mice by activating adiponectin/AMPK signaling

Abstract

The incidence of obesity has increased worldwide, leading to metabolic disorders such as hyperlipidemia and insulin resistance. Therefore, novel functional foods and therapeutic agents against obesity-related metabolic disorders are needed. We explored the effectiveness of the edible herb Heracleum dissectum Ledeb. (HD) against metabolic syndrome symptoms in a high-fat diet (60% of kcal) obesity mouse model. Metabolic syndrome was induced after 8 weeks of high-fat diet feeding, and HD extract (50 mg/kg) was administered by oral gavage during feeding. HD extract effectively decreased body weight gain and ameliorated the serum lipid status. HD extract also upregulated adiponectin/AMP-activated protein kinase (AMPK) signaling, and had anti-oxidation, anti-inflammation, and anti-insulin resistance effects. HD extract further elevated phosphorylation of AMPK and mitochondria biogenesis in the adipose tissue, resulting increased energy expenditure via the triglyceride/fatty acid cycle. Thus, HD extract could be considered a multi-targeting functional food candidate with novel molecular mechanisms. ？ 2021