Acetate decreases PVR/CD155 expression via PI3K/AKT pathway in cancer cells

Authors
Tran, Na LyLee, In KyuChoi, JungkyunKim, Sang-HeonOh, Seung Ja
Issue Date
2021-08-31
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Citation
BMB REPORTS, v.54, no.8, pp.431 - 436
Abstract
In recent years, restoring anti-tumor immunity has garnered a growing interest in cancer treatment As potential therapeutics, immune checkpoint inhibitors have demonstrated benefits in many clinical studies. Although various methods have been applied to suppress immune checkpoints to boost anti-tumor immunity, including the use of immune checkpoint inhibitors, there are still unmet clinical needs to improve the response rate of cancer treatment Here, we show that acetate can suppress the expression of poliovirus receptor (PVR/CD155), a ligand for immune checkpoint, in colon cancer cells. We demonstrated that acetate treatment could enhance effector responses of CD8(+) T cells by decreasing the expression of PVR/CD155 in cancer cells. We also found that acetate could reduce the expression of PVR/CD155 by deactivating the PI3K/AKT pathway. These results demonstrate that acetate-mediated expression of PVR/ CD155 in cancer cells might potentiate the anti-tumor immunity in the microenvironment of cancer. Our findings indicate that maintaining particular acetate concentrations could be a complementary strategy in current cancer treatment.
Keywords
CHAIN FATTY-ACIDS; INHIBITION; BLOCKADE; CHAIN FATTY-ACIDS; INHIBITION; BLOCKADE; Acetate; CD8(+); Colorectal cancer; PVR/CD155; Short-chain fatty acid
ISSN
1976-6696
URI
https://pubs.kist.re.kr/handle/201004/116574
DOI
10.5483/BMBRep.2021.54.8.060
Appears in Collections:
KIST Article > 2021
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