A Synthetic Strategy toward Eight-Membered Cyclic Amines by Cycloetherification and Claisen Rearrangement

Authors
Han, Seo-JungCavitt, Marchello A.Stoltz, Brian M.
Issue Date
2021-05
Publisher
American Chemical Society
Citation
Organic Letters, v.23, no.9, pp.3300 - 3303
Abstract
Eight-membered nitrogen-containing heterocycles were straightforwardly produced by a nickel-catalyzed cycloetherification and subsequent Claisen rearrangement of secondary and tertiary alcohols. In particular, a one-pot transformation was achieved with tertiary alcohols in moderate to good yields. This operationally simple reaction is tolerant of many functional groups and applicable to the synthesis of various medium-sized ring nitrogen-containing heterocycles.
ISSN
1523-7060
URI
https://pubs.kist.re.kr/handle/201004/117101
DOI
10.1021/acs.orglett.1c00763
Appears in Collections:
KIST Article > 2021
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