A Synthetic Strategy toward Eight-Membered Cyclic Amines by Cycloetherification and Claisen Rearrangement
- Authors
- Han, Seo-Jung; Cavitt, Marchello A.; Stoltz, Brian M.
- Issue Date
- 2021-05
- Publisher
- American Chemical Society
- Citation
- Organic Letters, v.23, no.9, pp.3300 - 3303
- Abstract
- Eight-membered nitrogen-containing heterocycles were straightforwardly produced by a nickel-catalyzed cycloetherification and subsequent Claisen rearrangement of secondary and tertiary alcohols. In particular, a one-pot transformation was achieved with tertiary alcohols in moderate to good yields. This operationally simple reaction is tolerant of many functional groups and applicable to the synthesis of various medium-sized ring nitrogen-containing heterocycles.
- ISSN
- 1523-7060
- URI
- https://pubs.kist.re.kr/handle/201004/117101
- DOI
- 10.1021/acs.orglett.1c00763
- Appears in Collections:
- KIST Article > 2021
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