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dc.contributor.authorKwak, Hankyul-
dc.contributor.authorKoh, Wuhyun-
dc.contributor.authorKim, Sangwoo-
dc.contributor.authorSong, Kiyeong-
dc.contributor.authorShin, Jeong-Im-
dc.contributor.authorLee, Jung Moo-
dc.contributor.authorLee, Elliot H.-
dc.contributor.authorBae, Jin Young-
dc.contributor.authorHa, Go Eun-
dc.contributor.authorOh, Ju-Eun-
dc.contributor.authorPark, Yongmin Mason-
dc.contributor.authorKim, Sunpil-
dc.contributor.authorFeng, Jiesi-
dc.contributor.authorLee, Seung Eun-
dc.contributor.authorChoi, Ji Won-
dc.contributor.authorKim, Ki Hun-
dc.contributor.authorKim, Yoo Sung-
dc.contributor.authorWoo, Junsung-
dc.contributor.authorLee, Dongsu-
dc.contributor.authorSon, Taehwang-
dc.contributor.authorKwon, Soon Woo-
dc.contributor.authorPark, Ki Duk-
dc.contributor.authorYoon, Bo-Eun-
dc.contributor.authorLee, Jaeick-
dc.contributor.authorLi, Yulong-
dc.contributor.authorLee, Hyunbeom-
dc.contributor.authorBae, Yong Chul-
dc.contributor.authorLee, C. Justin-
dc.contributor.authorCheong, Eunji-
dc.date.accessioned2024-01-19T16:04:31Z-
dc.date.available2024-01-19T16:04:31Z-
dc.date.created2021-09-02-
dc.date.issued2020-11-
dc.identifier.issn0896-6273-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/117896-
dc.description.abstractSensory discrimination is essential for survival. However, how sensory information is finely controlled in the brain is not well defined. Here, we show that astrocytes control tactile acuity via tonic inhibition in the thalamus. Mechanistically, diamine oxidase (DAO) and the subsequent aldehyde dehydrogenase 1a1 (Aldh1a1) convert putrescine into GABA, which is released via Best1 The GABA from astrocytes inhibits synaptically evoked firing at the lemniscal synapses to fine-tune the dynamic range of the stimulation-response relationship, the precision of spike timing, and tactile discrimination. Our findings reveal a novel role of astrocytes in the control of sensory acuity through tonic GABA release.-
dc.languageEnglish-
dc.publisherCELL PRESS-
dc.titleAstrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus-
dc.typeArticle-
dc.identifier.doi10.1016/j.neuron.2020.08.013-
dc.description.journalClass1-
dc.identifier.bibliographicCitationNEURON, v.108, no.4, pp.691 - +-
dc.citation.titleNEURON-
dc.citation.volume108-
dc.citation.number4-
dc.citation.startPage691-
dc.citation.endPage+-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000598177400015-
dc.identifier.scopusid2-s2.0-85091356334-
dc.relation.journalWebOfScienceCategoryNeurosciences-
dc.relation.journalResearchAreaNeurosciences & Neurology-
dc.type.docTypeArticle-
dc.subject.keywordPlusEXTRASYNAPTIC GABA(A) RECEPTORS-
dc.subject.keywordPlusVENTROBASAL THALAMUS-
dc.subject.keywordPlusRETICULAR NUCLEUS-
dc.subject.keywordPlusGENE-EXPRESSION-
dc.subject.keywordPlusNEURONS-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusCHANNELS-
dc.subject.keywordPlusRELEASE-
dc.subject.keywordPlusDISCRIMINATION-
dc.subject.keywordPlusPHYSIOLOGY-
dc.subject.keywordAuthoraldehyde dehydrogenase-
dc.subject.keywordAuthorastrocyte-
dc.subject.keywordAuthorBest1-
dc.subject.keywordAuthordiamine oxidase-
dc.subject.keywordAuthorsensory acuity-
dc.subject.keywordAuthortactile discrimination-
dc.subject.keywordAuthortemporal fidelity-
dc.subject.keywordAuthorthalamus-
dc.subject.keywordAuthortonic GABA-
dc.subject.keywordAuthortonic inhibition-
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