Surface Sensitive Analysis Device using Model Membrane and Challenges for Biosensor-chip

Abstract

Lipid membranes and their applications in analytical biochip devices represent a great tool for the study of membrane dynamics and the related biological phenomena. Lipid-membrane-assisted surface-sensitive sensors have employed to provide biological information as they improve molecular survivability as well as rule out incorrect signals arising from unwanted nonspecific binding between target molecules with sensor surfaces. To enhance the accuracy of the signal as well as the sensitivity of biochip sensors, a variety of strategies have been employed. Here, we introduce various types of in vitro model membrane platforms/techniques and discuss current challenges in the lipid-membrane-assisted surface-sensitive analytical sensors application.