Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Sun, In-Cheol | - |
dc.contributor.author | Ahn, Cheol-Hee | - |
dc.contributor.author | Kim, Kwangmeyung | - |
dc.contributor.author | Emelianov, Stanislav | - |
dc.date.accessioned | 2024-01-19T18:33:51Z | - |
dc.date.available | 2024-01-19T18:33:51Z | - |
dc.date.created | 2021-09-05 | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 1083-3668 | - |
dc.identifier.uri | https://pubs.kist.re.kr/handle/201004/119276 | - |
dc.description.abstract | Utility of glycol-chitosan-coated gold nanoparticles (GC-AuNPs) as a photoacoustic contrast agent for cancer cell imaging was demonstrated. Through the synergistic effect of glycol chitosan and gold nanoparticles, GC-AuNPs showed cellular uptake in breast cancer cells and resulted in strong photoacoustic signals in tissue-mimicking cell phantoms. The performance of GC-AuNPs as contrast agents was established with photoacoustic imaging and confirmed with dark-field microscopy. The cell phantoms displayed strong photoacoustic signals if cells were incubated more than 3 h with GC-AuNPs, compared with PEG-AuNPs that showed no photoacoustic signal increase. The enhanced photoacoustic signals originated from the plasmon coupling effect of GC-AuNPs after the cellular uptake in cancer cells. Importantly, photoacoustic imaging of cancer cells was achieved with GC-AuNPs-contrast agents that did not require antibodies or complex surface modification. The endocytosis of GC-AuNPs was also confirmed with dark-field microscopy. The results show that GC-AuNPs have potential as a photoacoustic contrast agent for cellular imaging including tumor tissue imaging. (C) The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. | - |
dc.language | English | - |
dc.publisher | SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS | - |
dc.subject | ULTRASOUND | - |
dc.subject | CARRIERS | - |
dc.title | Photoacoustic imaging of cancer cells with glycol-chitosan-coated gold nanoparticles as contrast agents | - |
dc.type | Article | - |
dc.identifier.doi | 10.1117/1.JBO.24.12.121903 | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOMEDICAL OPTICS, v.24, no.12 | - |
dc.citation.title | JOURNAL OF BIOMEDICAL OPTICS | - |
dc.citation.volume | 24 | - |
dc.citation.number | 12 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.wosid | 000508233000004 | - |
dc.identifier.scopusid | 2-s2.0-85071184953 | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Optics | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Optics | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ULTRASOUND | - |
dc.subject.keywordPlus | CARRIERS | - |
dc.subject.keywordAuthor | glycol chitosan | - |
dc.subject.keywordAuthor | gold nanoparticles | - |
dc.subject.keywordAuthor | photoacoustic imaging | - |
dc.subject.keywordAuthor | cancer imaging | - |
dc.subject.keywordAuthor | contrast agent | - |
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