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dc.contributor.authorSun, In-Cheol-
dc.contributor.authorAhn, Cheol-Hee-
dc.contributor.authorKim, Kwangmeyung-
dc.contributor.authorEmelianov, Stanislav-
dc.date.accessioned2024-01-19T18:33:51Z-
dc.date.available2024-01-19T18:33:51Z-
dc.date.created2021-09-05-
dc.date.issued2019-12-
dc.identifier.issn1083-3668-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/119276-
dc.description.abstractUtility of glycol-chitosan-coated gold nanoparticles (GC-AuNPs) as a photoacoustic contrast agent for cancer cell imaging was demonstrated. Through the synergistic effect of glycol chitosan and gold nanoparticles, GC-AuNPs showed cellular uptake in breast cancer cells and resulted in strong photoacoustic signals in tissue-mimicking cell phantoms. The performance of GC-AuNPs as contrast agents was established with photoacoustic imaging and confirmed with dark-field microscopy. The cell phantoms displayed strong photoacoustic signals if cells were incubated more than 3 h with GC-AuNPs, compared with PEG-AuNPs that showed no photoacoustic signal increase. The enhanced photoacoustic signals originated from the plasmon coupling effect of GC-AuNPs after the cellular uptake in cancer cells. Importantly, photoacoustic imaging of cancer cells was achieved with GC-AuNPs-contrast agents that did not require antibodies or complex surface modification. The endocytosis of GC-AuNPs was also confirmed with dark-field microscopy. The results show that GC-AuNPs have potential as a photoacoustic contrast agent for cellular imaging including tumor tissue imaging. (C) The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License.-
dc.languageEnglish-
dc.publisherSPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS-
dc.subjectULTRASOUND-
dc.subjectCARRIERS-
dc.titlePhotoacoustic imaging of cancer cells with glycol-chitosan-coated gold nanoparticles as contrast agents-
dc.typeArticle-
dc.identifier.doi10.1117/1.JBO.24.12.121903-
dc.description.journalClass1-
dc.identifier.bibliographicCitationJOURNAL OF BIOMEDICAL OPTICS, v.24, no.12-
dc.citation.titleJOURNAL OF BIOMEDICAL OPTICS-
dc.citation.volume24-
dc.citation.number12-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000508233000004-
dc.identifier.scopusid2-s2.0-85071184953-
dc.relation.journalWebOfScienceCategoryBiochemical Research Methods-
dc.relation.journalWebOfScienceCategoryOptics-
dc.relation.journalWebOfScienceCategoryRadiology, Nuclear Medicine & Medical Imaging-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaOptics-
dc.relation.journalResearchAreaRadiology, Nuclear Medicine & Medical Imaging-
dc.type.docTypeArticle-
dc.subject.keywordPlusULTRASOUND-
dc.subject.keywordPlusCARRIERS-
dc.subject.keywordAuthorglycol chitosan-
dc.subject.keywordAuthorgold nanoparticles-
dc.subject.keywordAuthorphotoacoustic imaging-
dc.subject.keywordAuthorcancer imaging-
dc.subject.keywordAuthorcontrast agent-
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KIST Article > 2019
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