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dc.contributor.authorKwon, Jaeyoung-
dc.contributor.authorKo, Keebeom-
dc.contributor.authorZhang, Lijun-
dc.contributor.authorZhao, Dong-
dc.contributor.authorYang, Hyun Ok-
dc.contributor.authorKwon, Hak Cheol-
dc.date.accessioned2024-01-19T18:34:02Z-
dc.date.available2024-01-19T18:34:02Z-
dc.date.created2021-09-04-
dc.date.issued2019-12-
dc.identifier.issn1420-3049-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/119288-
dc.description.abstractAutophagy is an important self-degradative mechanism that plays a key role in treating neurodegeneration diseases. This research aimed at discovering bioactive compounds from Aster koraiensis. A new triterpene saponin, astersaponin I (1), was isolated from the EtOH extract of A. koraiensis. The structure of 1 was characterized by spectroscopic methods, ECD calculation, and acid hydrolysis. The biochemical analysis showed that compound 1 significantly increased the expression of microtubule-associated protein 1A/1B light chain 3B (LC3-II) expression in SH-SY5Y cells, which indicates the induction of autophagy. Thus, further study may be needed to clarify whether compound 1 exerts beneficial effects on neurodegeneration diseases like Parkinson's disease through autophagy induction.-
dc.languageEnglish-
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)-
dc.titleAn Autophagy Inducing Triterpene Saponin Derived from Aster koraiensis-
dc.typeArticle-
dc.identifier.doi10.3390/molecules24244489-
dc.description.journalClass1-
dc.identifier.bibliographicCitationMolecules, v.24, no.24-
dc.citation.titleMolecules-
dc.citation.volume24-
dc.citation.number24-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000507299600067-
dc.identifier.scopusid2-s2.0-85076267863-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusCONSTITUENTS-
dc.subject.keywordPlusDISEASE-
dc.subject.keywordPlusHEALTH-
dc.subject.keywordAuthorAster koraiensis-
dc.subject.keywordAuthortriterpene saponin-
dc.subject.keywordAuthorautophagy-
dc.subject.keywordAuthornatural products-
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KIST Article > 2019
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