Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Jaeyoung | - |
dc.contributor.author | Ko, Keebeom | - |
dc.contributor.author | Zhang, Lijun | - |
dc.contributor.author | Zhao, Dong | - |
dc.contributor.author | Yang, Hyun Ok | - |
dc.contributor.author | Kwon, Hak Cheol | - |
dc.date.accessioned | 2024-01-19T18:34:02Z | - |
dc.date.available | 2024-01-19T18:34:02Z | - |
dc.date.created | 2021-09-04 | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://pubs.kist.re.kr/handle/201004/119288 | - |
dc.description.abstract | Autophagy is an important self-degradative mechanism that plays a key role in treating neurodegeneration diseases. This research aimed at discovering bioactive compounds from Aster koraiensis. A new triterpene saponin, astersaponin I (1), was isolated from the EtOH extract of A. koraiensis. The structure of 1 was characterized by spectroscopic methods, ECD calculation, and acid hydrolysis. The biochemical analysis showed that compound 1 significantly increased the expression of microtubule-associated protein 1A/1B light chain 3B (LC3-II) expression in SH-SY5Y cells, which indicates the induction of autophagy. Thus, further study may be needed to clarify whether compound 1 exerts beneficial effects on neurodegeneration diseases like Parkinson's disease through autophagy induction. | - |
dc.language | English | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | An Autophagy Inducing Triterpene Saponin Derived from Aster koraiensis | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/molecules24244489 | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | Molecules, v.24, no.24 | - |
dc.citation.title | Molecules | - |
dc.citation.volume | 24 | - |
dc.citation.number | 24 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.wosid | 000507299600067 | - |
dc.identifier.scopusid | 2-s2.0-85076267863 | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | HEALTH | - |
dc.subject.keywordAuthor | Aster koraiensis | - |
dc.subject.keywordAuthor | triterpene saponin | - |
dc.subject.keywordAuthor | autophagy | - |
dc.subject.keywordAuthor | natural products | - |
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