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dc.contributor.authorLee, Jongha-
dc.contributor.authorCho, Hye Rim-
dc.contributor.authorCha, Gi Doo-
dc.contributor.authorSeo, Hyunseon-
dc.contributor.authorLee, Seunghyun-
dc.contributor.authorPark, Chul-Kee-
dc.contributor.authorKim, Jin Wook-
dc.contributor.authorQiao, Shutao-
dc.contributor.authorWang, Liu-
dc.contributor.authorKang, Dayoung-
dc.contributor.authorKang, Taegyu-
dc.contributor.authorIchikawa, Tomotsugu-
dc.contributor.authorKim, Jonghoon-
dc.contributor.authorLee, Hakyong-
dc.contributor.authorLee, Woongchan-
dc.contributor.authorKim, Sanghoek-
dc.contributor.authorLee, Soon-Tae-
dc.contributor.authorLu, Nanshu-
dc.contributor.authorHyeon, Taeghwan-
dc.contributor.authorChoi, Seung Hong-
dc.contributor.authorKim, Dae-Hyeong-
dc.date.accessioned2024-01-19T19:00:30Z-
dc.date.available2024-01-19T19:00:30Z-
dc.date.created2022-01-25-
dc.date.issued2019-11-
dc.identifier.issn2041-1723-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/119348-
dc.description.abstractImplantation of biodegradable wafers near the brain surgery site to deliver anti-cancer agents which target residual tumor cells by bypassing the blood-brain barrier has been a promising method for brain tumor treatment. However, further improvement in the prognosis is still necessary. We herein present novel materials and device technologies for drug delivery to brain tumors, i.e., a flexible, sticky, and biodegradable drug-loaded patch integrated with wireless electronics for controlled intracranial drug delivery through mild-thermic actuation. The flexible and bifacially-designed sticky/hydrophobic device allows conformal adhesion on the brain surgery site and provides spatially-controlled and temporarily-extended drug delivery to brain tumors while minimizing unintended drug leakage to the cerebrospinal fluid. Biodegradation of the entire device minimizes potential neurological side-effects. Application of the device to the mouse model confirms tumor volume suppression and improved survival rate. Demonstration in a large animal model (canine model) exhibited its potential for human application.-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.titleFlexible, sticky, and biodegradable wireless device for drug delivery to brain tumors-
dc.typeArticle-
dc.identifier.doi10.1038/s41467-019-13198-y-
dc.description.journalClass1-
dc.identifier.bibliographicCitationNature Communications, v.10-
dc.citation.titleNature Communications-
dc.citation.volume10-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000496713300002-
dc.identifier.scopusid2-s2.0-85075115513-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.type.docTypeArticle-
dc.subject.keywordPlusGLIOBLASTOMA-
dc.subject.keywordPlusSURVIVAL-
dc.subject.keywordPlusPOLYMER-
dc.subject.keywordPlusTEMOZOLOMIDE-
dc.subject.keywordPlusELECTRONICS-
dc.subject.keywordPlusTRANSISTORS-
dc.subject.keywordPlusCARMUSTINE-
dc.subject.keywordPlusPHENOTYPES-
dc.subject.keywordPlusINVASION-
dc.subject.keywordPlusTHERAPY-
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KIST Article > 2019
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