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dc.contributor.authorFerguson, Fleur M.-
dc.contributor.authorDoctor, Zainab M.-
dc.contributor.authorFicarro, Scott B.-
dc.contributor.authorMarto, Jarrod A.-
dc.contributor.authorKim, Nam Doo-
dc.contributor.authorSim, Taebo-
dc.contributor.authorGray, Nathanael S.-
dc.date.accessioned2024-01-19T19:31:55Z-
dc.date.available2024-01-19T19:31:55Z-
dc.date.created2022-01-25-
dc.date.issued2019-08-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/119699-
dc.description.abstractThe TAIRE family of kinases are an understudied branch of the CDK kinase family, that have been implicated in a number of cancers. This manuscript describes the design, synthesis and SAR of covalent CDK14 inhibitors, culminating in identification of FMF-04-159-2, a potent, covalent CDK14 inhibitor with a TAIRE kinase biased selectivity profile.-
dc.languageEnglish-
dc.publisherPergamon Press Ltd.-
dc.titleSynthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2019.05.024-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, v.29, no.15, pp.1985 - 1993-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.volume29-
dc.citation.number15-
dc.citation.startPage1985-
dc.citation.endPage1993-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000471750200024-
dc.identifier.scopusid2-s2.0-85066508646-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusPROLIFERATION-
dc.subject.keywordPlusINVASION-
dc.subject.keywordAuthorCovalent kinase inhibitor-
dc.subject.keywordAuthorCDK14-
dc.subject.keywordAuthorTAIRE kinase-
dc.subject.keywordAuthorCDK15-
dc.subject.keywordAuthorCDK16-
dc.subject.keywordAuthorCDK17-
dc.subject.keywordAuthorCDK18-
dc.subject.keywordAuthorCDK inhibitor-
dc.subject.keywordAuthorMitosis-
dc.subject.keywordAuthorCell cycle-
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