Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, JinSeok | - |
dc.contributor.author | Kim, Deok-Ho | - |
dc.contributor.author | Shah, Sagar R. | - |
dc.contributor.author | Kim, Hong-Nam | - |
dc.contributor.author | Kshitiz | - |
dc.contributor.author | Kim, Peter | - |
dc.contributor.author | Quinones-Hinojosa, Alfredo | - |
dc.contributor.author | Levchenko, Andre | - |
dc.date.accessioned | 2024-01-19T20:02:05Z | - |
dc.date.available | 2024-01-19T20:02:05Z | - |
dc.date.created | 2021-09-02 | - |
dc.date.issued | 2019-06 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://pubs.kist.re.kr/handle/201004/119961 | - |
dc.description.abstract | Collective cell migration occurs in many patho-physiological states, including wound healing and invasive cancer growth. The integrity of the expanding epithelial sheets depends on extracellular cues, including cell-cell and cell-matrix interactions. We show that the nano-scale topography of the extracellular matrix underlying epithelial cell layers can strongly affect the speed and morphology of the fronts of the expanding sheet, triggering partial and complete epithelial-mesenchymal transitions (EMTs). We further demonstrate that this behavior depends on the mechano-sensitivity of the transcription regulator YAP and two new YAP-mediated cross-regulating feedback mechanisms: Wilms Tumor-1-YAP-mediated downregulation of E-cadherin, loosening cell-cell contacts, and YAP-TRIO-Merlin mediated regulation of Rho GTPase family proteins, enhancing cell migration. These YAP-dependent feedback loops result in a switch-like change in the signaling and the expression of EMT-related markers, leading to a robust enhancement in invasive cell spread, which may lead to a worsened clinical outcome in renal and other cancers. | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Switch-like enhancement of epithelial-mesenchymal transition by YAP through feedback regulation of WT1 and Rho-family GTPases | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41467-019-10729-5 | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | Nature Communications, v.10 | - |
dc.citation.title | Nature Communications | - |
dc.citation.volume | 10 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.wosid | 000472840400012 | - |
dc.identifier.scopusid | 2-s2.0-85068026123 | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | COLLECTIVE CELL-MIGRATION | - |
dc.subject.keywordPlus | MEDIATES CONTACT INHIBITION | - |
dc.subject.keywordPlus | E-CADHERIN | - |
dc.subject.keywordPlus | MECHANICAL-PROPERTIES | - |
dc.subject.keywordPlus | TOPOGRAPHIC GUIDANCE | - |
dc.subject.keywordPlus | FOCAL ADHESIONS | - |
dc.subject.keywordPlus | WILMS-TUMOR | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | YAP/TAZ | - |
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