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dc.contributor.authorPark, JinSeok-
dc.contributor.authorKim, Deok-Ho-
dc.contributor.authorShah, Sagar R.-
dc.contributor.authorKim, Hong-Nam-
dc.contributor.authorKshitiz-
dc.contributor.authorKim, Peter-
dc.contributor.authorQuinones-Hinojosa, Alfredo-
dc.contributor.authorLevchenko, Andre-
dc.date.accessioned2024-01-19T20:02:05Z-
dc.date.available2024-01-19T20:02:05Z-
dc.date.created2021-09-02-
dc.date.issued2019-06-
dc.identifier.issn2041-1723-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/119961-
dc.description.abstractCollective cell migration occurs in many patho-physiological states, including wound healing and invasive cancer growth. The integrity of the expanding epithelial sheets depends on extracellular cues, including cell-cell and cell-matrix interactions. We show that the nano-scale topography of the extracellular matrix underlying epithelial cell layers can strongly affect the speed and morphology of the fronts of the expanding sheet, triggering partial and complete epithelial-mesenchymal transitions (EMTs). We further demonstrate that this behavior depends on the mechano-sensitivity of the transcription regulator YAP and two new YAP-mediated cross-regulating feedback mechanisms: Wilms Tumor-1-YAP-mediated downregulation of E-cadherin, loosening cell-cell contacts, and YAP-TRIO-Merlin mediated regulation of Rho GTPase family proteins, enhancing cell migration. These YAP-dependent feedback loops result in a switch-like change in the signaling and the expression of EMT-related markers, leading to a robust enhancement in invasive cell spread, which may lead to a worsened clinical outcome in renal and other cancers.-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.titleSwitch-like enhancement of epithelial-mesenchymal transition by YAP through feedback regulation of WT1 and Rho-family GTPases-
dc.typeArticle-
dc.identifier.doi10.1038/s41467-019-10729-5-
dc.description.journalClass1-
dc.identifier.bibliographicCitationNature Communications, v.10-
dc.citation.titleNature Communications-
dc.citation.volume10-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000472840400012-
dc.identifier.scopusid2-s2.0-85068026123-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.type.docTypeArticle-
dc.subject.keywordPlusCOLLECTIVE CELL-MIGRATION-
dc.subject.keywordPlusMEDIATES CONTACT INHIBITION-
dc.subject.keywordPlusE-CADHERIN-
dc.subject.keywordPlusMECHANICAL-PROPERTIES-
dc.subject.keywordPlusTOPOGRAPHIC GUIDANCE-
dc.subject.keywordPlusFOCAL ADHESIONS-
dc.subject.keywordPlusWILMS-TUMOR-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusCOMPLEX-
dc.subject.keywordPlusYAP/TAZ-
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