Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Jin, Su-Eon | - |
dc.contributor.author | Jin, Jun Eon | - |
dc.contributor.author | Hwang, Woochul | - |
dc.contributor.author | Hong, Seok Won | - |
dc.date.accessioned | 2024-01-19T20:32:54Z | - |
dc.date.available | 2024-01-19T20:32:54Z | - |
dc.date.created | 2021-09-05 | - |
dc.date.issued | 2019-03 | - |
dc.identifier.issn | 1176-9114 | - |
dc.identifier.uri | https://pubs.kist.re.kr/handle/201004/120262 | - |
dc.description.abstract | Background: Zinc oxide (ZnO) nanoparticles and their networks have been developed for use in various applications such as gas sensors and semiconductors. Aim: In this study, their antibacterial activity against Escherichia coli under dual ultraviolet (UV) irradiation for disinfection was investigated. Materials and methods: ZnO nanoparticles were synthesized and immobilized onto silicon (Si) wafers by self-assembly. The physicochemical properties and antibacterial activity of ZnO nanoparticles and their networks were evaluated. Gene ontology was analyzed and toxicity levels were also monitored. Results: Synthesized ZnO nanoparticles were spherical nanocrystals (<100 nm; Zn, 47%; O, 53%) that formed macro-mesoporous three-dimensional nanostructures on Si wafers in a concentration-dependent manner. ZnO nanoparticles and their networks on Si wafers had an excellent antibacterial activity against E. coli under dual UV irradiation (>log CFU/mL). Specifically, arrayed ZnO nanoparticle networks showed superior activity compared with free synthesized ZnO nanoparticles. Oxidative stress-responsive proteins in E. coli were identified and categorized, which indicated antibacterial activity. Synthesized ZnO nanoparticles were less cytotoxic in HaCaT with an IC50 of 6.632 mg/mL, but phototoxic in Balb/c 3T3. Conclusion: The results suggested that ZnO nanoparticles and their networks can be promising photocatalytic antibiotics for use in next-generation disinfection systems. Their application could also be extended to industrial and clinical use as effective and safe photocatalytic antibiotics. | - |
dc.language | English | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.title | Photocatalytic antibacterial application of zinc oxide nanoparticles and self-assembled networks under dual UV irradiation for enhanced disinfection | - |
dc.type | Article | - |
dc.identifier.doi | 10.2147/IJN.S192277 | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF NANOMEDICINE, v.14, pp.1737 - 1751 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.citation.volume | 14 | - |
dc.citation.startPage | 1737 | - |
dc.citation.endPage | 1751 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.wosid | 000461294500001 | - |
dc.identifier.scopusid | 2-s2.0-85063278957 | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | ANTIMICROBIAL ACTIVITY | - |
dc.subject.keywordPlus | POROUS MATERIALS | - |
dc.subject.keywordPlus | TIO2 | - |
dc.subject.keywordPlus | REGULATOR | - |
dc.subject.keywordPlus | DJ-1 | - |
dc.subject.keywordPlus | YAJL | - |
dc.subject.keywordPlus | OXYR | - |
dc.subject.keywordAuthor | zinc oxide nanoparticles | - |
dc.subject.keywordAuthor | immobilization | - |
dc.subject.keywordAuthor | dual UV | - |
dc.subject.keywordAuthor | antibacterial | - |
dc.subject.keywordAuthor | disinfection | - |
dc.subject.keywordAuthor | toxicity | - |
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