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dc.contributor.authorJin, Su-Eon-
dc.contributor.authorJin, Jun Eon-
dc.contributor.authorHwang, Woochul-
dc.contributor.authorHong, Seok Won-
dc.date.accessioned2024-01-19T20:32:54Z-
dc.date.available2024-01-19T20:32:54Z-
dc.date.created2021-09-05-
dc.date.issued2019-03-
dc.identifier.issn1176-9114-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/120262-
dc.description.abstractBackground: Zinc oxide (ZnO) nanoparticles and their networks have been developed for use in various applications such as gas sensors and semiconductors. Aim: In this study, their antibacterial activity against Escherichia coli under dual ultraviolet (UV) irradiation for disinfection was investigated. Materials and methods: ZnO nanoparticles were synthesized and immobilized onto silicon (Si) wafers by self-assembly. The physicochemical properties and antibacterial activity of ZnO nanoparticles and their networks were evaluated. Gene ontology was analyzed and toxicity levels were also monitored. Results: Synthesized ZnO nanoparticles were spherical nanocrystals (<100 nm; Zn, 47%; O, 53%) that formed macro-mesoporous three-dimensional nanostructures on Si wafers in a concentration-dependent manner. ZnO nanoparticles and their networks on Si wafers had an excellent antibacterial activity against E. coli under dual UV irradiation (>log CFU/mL). Specifically, arrayed ZnO nanoparticle networks showed superior activity compared with free synthesized ZnO nanoparticles. Oxidative stress-responsive proteins in E. coli were identified and categorized, which indicated antibacterial activity. Synthesized ZnO nanoparticles were less cytotoxic in HaCaT with an IC50 of 6.632 mg/mL, but phototoxic in Balb/c 3T3. Conclusion: The results suggested that ZnO nanoparticles and their networks can be promising photocatalytic antibiotics for use in next-generation disinfection systems. Their application could also be extended to industrial and clinical use as effective and safe photocatalytic antibiotics.-
dc.languageEnglish-
dc.publisherDOVE MEDICAL PRESS LTD-
dc.titlePhotocatalytic antibacterial application of zinc oxide nanoparticles and self-assembled networks under dual UV irradiation for enhanced disinfection-
dc.typeArticle-
dc.identifier.doi10.2147/IJN.S192277-
dc.description.journalClass1-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF NANOMEDICINE, v.14, pp.1737 - 1751-
dc.citation.titleINTERNATIONAL JOURNAL OF NANOMEDICINE-
dc.citation.volume14-
dc.citation.startPage1737-
dc.citation.endPage1751-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000461294500001-
dc.identifier.scopusid2-s2.0-85063278957-
dc.relation.journalWebOfScienceCategoryNanoscience & Nanotechnology-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.type.docTypeArticle-
dc.subject.keywordPlusESCHERICHIA-COLI-
dc.subject.keywordPlusANTIMICROBIAL ACTIVITY-
dc.subject.keywordPlusPOROUS MATERIALS-
dc.subject.keywordPlusTIO2-
dc.subject.keywordPlusREGULATOR-
dc.subject.keywordPlusDJ-1-
dc.subject.keywordPlusYAJL-
dc.subject.keywordPlusOXYR-
dc.subject.keywordAuthorzinc oxide nanoparticles-
dc.subject.keywordAuthorimmobilization-
dc.subject.keywordAuthordual UV-
dc.subject.keywordAuthorantibacterial-
dc.subject.keywordAuthordisinfection-
dc.subject.keywordAuthortoxicity-
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KIST Article > 2019
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