Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Jun Yeon | - |
dc.contributor.author | Park, Do Hwi | - |
dc.contributor.author | Jeon, Youngsic | - |
dc.contributor.author | Kim, Young-Joo | - |
dc.contributor.author | Lee, Jaemin | - |
dc.contributor.author | Shin, Myoung-Sook | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Hwang, Gwi Seo | - |
dc.contributor.author | Kim, Hyun Young | - |
dc.contributor.author | Yamabe, Noriko | - |
dc.date.accessioned | 2024-01-19T21:32:48Z | - |
dc.date.available | 2024-01-19T21:32:48Z | - |
dc.date.created | 2021-09-05 | - |
dc.date.issued | 2018-10-15 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://pubs.kist.re.kr/handle/201004/120784 | - |
dc.description.abstract | Metastasis is responsible for the great majority of deaths in cancer patients. Matrix metalloproteinases (MMPs) have critical functions in cancer metastasis. Especially, MMP-2 and MMP-9 play a major role in tumor-cell migration and invasion. Therefore, to first find out the inhibitory effect of eupatilin on expression of MMPs in SNU182 cells, we used quantitative real-rime PCR to measure MMP-2 and MMP-9 mRNA levels. Eupatilin suppressed transcription of MMP-2 in SNU182 cells more than did the corresponding controls. Also, eupatilin significantly blocked tube formation when treated with a concentration of 3.125 or 6.25 mu g/mL on human umbilical vein vascular endothelial cells (HUVECs). Eupatilin induced significant anti-angiogenic potential associated with down-regulation of hypoxia-inducible factor 1-alpha (HIF-1 alpha), vascular endothelial growth factor (VEGF), and phosphorylated Akt expression. Thus, tube-formation inhibition and MMP-2-mediated migration are likely to be important therapeutic targets of eupatilin in hepatocellular carcinoma metastasis. | - |
dc.language | English | - |
dc.publisher | Pergamon Press Ltd. | - |
dc.subject | NITRIC-OXIDE SYNTHASE | - |
dc.subject | MATRIX METALLOPROTEINASES | - |
dc.subject | EXPRESSION | - |
dc.subject | CARCINOMA | - |
dc.subject | PATHOGENESIS | - |
dc.subject | COLLAGENASE | - |
dc.subject | MIGRATION | - |
dc.subject | EXTRACT | - |
dc.subject | CELLS | - |
dc.subject | ACID | - |
dc.title | Eupatilin inhibits angiogenesis-mediated human hepatocellular metastasis by reducing MMP-2 and VEGF signaling | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bmcl.2018.08.034 | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | Bioorganic & Medicinal Chemistry Letters, v.28, no.19, pp.3150 - 3154 | - |
dc.citation.title | Bioorganic & Medicinal Chemistry Letters | - |
dc.citation.volume | 28 | - |
dc.citation.number | 19 | - |
dc.citation.startPage | 3150 | - |
dc.citation.endPage | 3154 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.wosid | 000446034100003 | - |
dc.identifier.scopusid | 2-s2.0-85054083552 | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | MATRIX METALLOPROTEINASES | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | COLLAGENASE | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordAuthor | Eupatilin | - |
dc.subject.keywordAuthor | Metastasis | - |
dc.subject.keywordAuthor | HUVEC | - |
dc.subject.keywordAuthor | MMPs | - |
dc.subject.keywordAuthor | VEGF | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.