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dc.contributor.authorShafiq, Muhammad-
dc.contributor.authorKong, Deling-
dc.contributor.authorKim, Soo Hyun-
dc.date.accessioned2024-01-20T00:32:01Z-
dc.date.available2024-01-20T00:32:01Z-
dc.date.created2021-09-04-
dc.date.issued2017-10-
dc.identifier.issn1549-3296-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/122246-
dc.description.abstractThe design of bioactive scaffolds that can invoke host's own regenerative capabilities and facilitate endogenous tissue repair hold great promise. This study aims to evaluate the potential of stromal cell-derived factor 1 alpha (SDF-1)-derived peptide and heparin tethered poly(L-lactide-co-epsilon-caprolactone) (PLCL) copolymers for blood vessel regeneration applications. Amino acid analysis and toluidine blue assays confirm successful conjugation of SDF-1 peptide and heparin with the PLCL copolymers. Assessment of biocompatibility after subcutaneous implantation in rats discloses higher cell infiltration in SDF-1 peptide (SDF-1 group) or SDF-1 peptide and heparin (SDF-1/heparin group) than the control group. SDF-1 and SDF-1/heparin grafts also show more numbers of laminin(+) blood vessels, CD90(+) stem cells, and alpha smooth muscle actin(+) cells than the control group. However, SDF-1 and SDF-1/heparin groups did not significantly differ in terms of blood vessel regeneration and stem cell recruitment. Evaluation of the inflammatory response reveal less numbers of CD68(+) macrophages in SDF-1 and SDF-1/heparin groups compared with the control group; whereas three groups show similar numbers of CD206(+) macrophages. These results indicate that completely synthetic, cell-free grafts can attract endogenous cells and enhance tissue repair. Bioactive polyesters can be fabricated into different shapes and structures for various tissue engineering applications. (c) 2017 Wiley Periodicals, Inc. J Biomater Res Part A: 105A: 2670-2684, 2017-
dc.languageEnglish-
dc.publisherWILEY-
dc.subjectENGINEERED VASCULAR GRAFTS-
dc.subjectBLOOD-VESSELS-
dc.subjectCOVALENT IMMOBILIZATION-
dc.subjectLOCAL-DELIVERY-
dc.subjectGROWTH-FACTOR-
dc.subjectREGENERATION-
dc.subjectHEPARIN-
dc.subjectPOLY(L-LACTIDE-CO-EPSILON-CAPROLACTONE)-
dc.subjectSCAFFOLDS-
dc.subjectENDOTHELIALIZATION-
dc.titleSDF-1 peptide tethered polyester facilitates tissue repair by endogenous cell mobilization and recruitment-
dc.typeArticle-
dc.identifier.doi10.1002/jbm.a.36130-
dc.description.journalClass1-
dc.identifier.bibliographicCitationJOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, v.105, no.10, pp.2670 - 2684-
dc.citation.titleJOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A-
dc.citation.volume105-
dc.citation.number10-
dc.citation.startPage2670-
dc.citation.endPage2684-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000408493200003-
dc.identifier.scopusid2-s2.0-85021207086-
dc.relation.journalWebOfScienceCategoryEngineering, Biomedical-
dc.relation.journalWebOfScienceCategoryMaterials Science, Biomaterials-
dc.relation.journalResearchAreaEngineering-
dc.relation.journalResearchAreaMaterials Science-
dc.type.docTypeArticle-
dc.subject.keywordPlusENGINEERED VASCULAR GRAFTS-
dc.subject.keywordPlusBLOOD-VESSELS-
dc.subject.keywordPlusCOVALENT IMMOBILIZATION-
dc.subject.keywordPlusLOCAL-DELIVERY-
dc.subject.keywordPlusGROWTH-FACTOR-
dc.subject.keywordPlusREGENERATION-
dc.subject.keywordPlusHEPARIN-
dc.subject.keywordPlusPOLY(L-LACTIDE-CO-EPSILON-CAPROLACTONE)-
dc.subject.keywordPlusSCAFFOLDS-
dc.subject.keywordPlusENDOTHELIALIZATION-
dc.subject.keywordAuthorstem cell recruitment-
dc.subject.keywordAuthorin situ tissue regeneration-
dc.subject.keywordAuthorvascular graft-
dc.subject.keywordAuthorSDF1--
dc.subject.keywordAuthorpolyester-
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