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dc.contributor.authorHong, Jin Ri-
dc.contributor.authorChoo, Hyunah-
dc.contributor.authorNam, Ghilsoo-
dc.date.accessioned2024-01-20T00:33:12Z-
dc.date.available2024-01-20T00:33:12Z-
dc.date.created2021-09-05-
dc.date.issued2017-09-01-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/122306-
dc.description.abstractA novel series of arylsulfonylaminomethyl-3-(1-phenyl-5-isopropyl)pyrazoles was evaluated for serotonin receptor subtype 6 (5-HT6R) antagonistic effects in vitro. We also investigated their neuropathic pain-alleviating effects in vivo using a rat spinal nerve ligation (SNL) model. Bicyclic aromatic sulfonamino groups, such as naphthalene and quinolin-substituted derivatives, showed good 5-HT6 inhibitory activity in vitro. Among them, selected compounds, 12 and 13, having 8-quinoylsulfonamino groups, showed potent neuropathic pain-alleviating effects in the rat model. (C) 2017 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPergamon Press Ltd.-
dc.subjectALZHEIMERS-DISEASE-
dc.subjectMEMORY-
dc.subjectRAT-
dc.titleNeuropathic pain-alleviating effects of pyrazole-conjugated arylsulfonamides as 5-HT6 receptor antagonists-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2017.07.031-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, v.27, no.17, pp.4146 - 4149-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.volume27-
dc.citation.number17-
dc.citation.startPage4146-
dc.citation.endPage4149-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000410462500038-
dc.identifier.scopusid2-s2.0-85024094337-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusALZHEIMERS-DISEASE-
dc.subject.keywordPlusMEMORY-
dc.subject.keywordPlusRAT-
dc.subject.keywordAuthorArylsulfonylaminomethylpyrazole-
dc.subject.keywordAuthorNeuropathic pain-
dc.subject.keywordAuthor5-HT6 receptor antagonist-
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