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dc.contributor.authorKim, TaeHun-
dc.contributor.authorYang, Ha Yun-
dc.contributor.authorPark, Beoung Gun-
dc.contributor.authorJung, Seo Yun-
dc.contributor.authorPark, Jong-Hyun-
dc.contributor.authorPark, Ki Duk-
dc.contributor.authorMin, Sun-Joon-
dc.contributor.authorTae, Jinsung-
dc.contributor.authorYang, Hyejin-
dc.contributor.authorCho, Suengmok-
dc.contributor.authorCho, Sung Jin-
dc.contributor.authorSong, Hyundong-
dc.contributor.authorMook-Jung, Inhee-
dc.contributor.authorLee, Jiyoun-
dc.contributor.authorPae, Ae Nim-
dc.date.accessioned2024-01-20T02:31:52Z-
dc.date.available2024-01-20T02:31:52Z-
dc.date.created2021-09-04-
dc.date.issued2017-01-05-
dc.identifier.issn0223-5234-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/123219-
dc.description.abstractIn this study, we designed a library of compounds based on the structures of well-known ligands of the 18 kDa translocator protein (TSPO), one of the putative components of the mPTP. We performed diverse mitochondrial functional assays to assess their ability to restore cells from A beta-induced toxicity in vitro and in vivo. Among tested compounds, compound 25 effectively improved cognitive function in animal models of AD. Given the excellent in vitro and in vivo activity and a favorable pharmacokinetic profile of compound 25, we believe that it can serve as a promising lead compound for a potential treatment option for AD. (C) 2016 Elsevier Masson SAS. All rights reserved.-
dc.languageEnglish-
dc.publisherELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER-
dc.subjectPERMEABILITY TRANSITION PORE-
dc.subjectAMYLOID-BETA-
dc.subjectCYCLOPHILIN-D-
dc.subjectA-BETA-
dc.subjectINHIBITOR-
dc.subjectTSPO-
dc.subjectREPERFUSION-
dc.subjectDYSFUNCTION-
dc.subjectHYPOTHESIS-
dc.subjectDIAGNOSIS-
dc.titleDiscovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease-
dc.typeArticle-
dc.identifier.doi10.1016/j.ejmech.2016.11.017-
dc.description.journalClass1-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.125, pp.1172 - 1192-
dc.citation.titleEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY-
dc.citation.volume125-
dc.citation.startPage1172-
dc.citation.endPage1192-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000390496600094-
dc.identifier.scopusid2-s2.0-84995688336-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.type.docTypeArticle-
dc.subject.keywordPlusPERMEABILITY TRANSITION PORE-
dc.subject.keywordPlusAMYLOID-BETA-
dc.subject.keywordPlusCYCLOPHILIN-D-
dc.subject.keywordPlusA-BETA-
dc.subject.keywordPlusINHIBITOR-
dc.subject.keywordPlusTSPO-
dc.subject.keywordPlusREPERFUSION-
dc.subject.keywordPlusDYSFUNCTION-
dc.subject.keywordPlusHYPOTHESIS-
dc.subject.keywordPlusDIAGNOSIS-
dc.subject.keywordAuthorTranslocator protein-
dc.subject.keywordAuthorTSPO-
dc.subject.keywordAuthorMitochondrial permeability transition pore-
dc.subject.keywordAuthorAlzheimer&apos-
dc.subject.keywordAuthors disease-
dc.subject.keywordAuthorMitochondrial dysfunction-
dc.subject.keywordAuthorA beta-
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