DSpace at KISTKIST Article2017

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dc.contributor.authorJin, Jun-O-
dc.contributor.authorPark, Haein-
dc.contributor.authorZhang, Wei-
dc.contributor.authorde Vries, Jan Willem-
dc.contributor.authorGruszka, Agnieszka-
dc.contributor.authorLee, Myung Won-
dc.contributor.authorAhn, Dae-Ro-
dc.contributor.authorHerrmann, Andreas-
dc.contributor.authorKwak, Minseok-
dc.date.accessioned2024-01-20T02:32:26Z-
dc.date.available2024-01-20T02:32:26Z-
dc.date.created2021-09-05-
dc.date.issued2017-01-
dc.identifier.issn0142-9612-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/123249-
dc.description.abstractWe introduce a versatile carrier system for in vitro and in vivo immune stimulation based on soft matter DNA nanoparticles (NPs). The incorporation of lipid-modified nucleotides into DNA strands enables the formation of micelles of uniform size. In a single self-assembly step, the micelles can be equipped with immune adjuvant (CpG) motifs and fluorescent probes. The immunological effects of CpG confined at the NP surface were studied in a comprehensive manner in animal experiments. Dose-dependent activation of spleen dendritic cells (DCs) by CpG-conjugated NP was observed, which was accompanied by the pronounced up-regulation of co-stimulatory molecule and cytokine production. (C) 2016 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherELSEVIER SCI LTD-
dc.subjectBLOCK-COPOLYMER MICELLES-
dc.subjectDENDRITIC CELLS-
dc.subjectIMMUNE-RESPONSE-
dc.subjectCANCER-
dc.subjectIMMUNOSTIMULATION-
dc.subjectNANOSTRUCTURES-
dc.subjectNANOTECHNOLOGY-
dc.subjectAMPHIPHILES-
dc.subjectMACROPHAGES-
dc.subjectMATURATION-
dc.titleModular delivery of CpG-incorporated lipid-DNA nanoparticles for spleen DC activation-
dc.typeArticle-
dc.identifier.doi10.1016/j.biomaterials.2016.11.020-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOMATERIALS, v.115, pp.81 - 89-
dc.citation.titleBIOMATERIALS-
dc.citation.volume115-
dc.citation.startPage81-
dc.citation.endPage89-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000390642100008-
dc.identifier.scopusid2-s2.0-84997017340-
dc.relation.journalWebOfScienceCategoryEngineering, Biomedical-
dc.relation.journalWebOfScienceCategoryMaterials Science, Biomaterials-
dc.relation.journalResearchAreaEngineering-
dc.relation.journalResearchAreaMaterials Science-
dc.type.docTypeArticle-
dc.subject.keywordPlusBLOCK-COPOLYMER MICELLES-
dc.subject.keywordPlusDENDRITIC CELLS-
dc.subject.keywordPlusIMMUNE-RESPONSE-
dc.subject.keywordPlusCANCER-
dc.subject.keywordPlusIMMUNOSTIMULATION-
dc.subject.keywordPlusNANOSTRUCTURES-
dc.subject.keywordPlusNANOTECHNOLOGY-
dc.subject.keywordPlusAMPHIPHILES-
dc.subject.keywordPlusMACROPHAGES-
dc.subject.keywordPlusMATURATION-
dc.subject.keywordAuthorDendritic cells-
dc.subject.keywordAuthorImmunology-
dc.subject.keywordAuthorAdjuvants-
dc.subject.keywordAuthorNanomedicine-
dc.subject.keywordAuthorDNA nanotechnology-
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