Full metadata record

DC Field Value Language
dc.contributor.authorKang, Joon Hee-
dc.contributor.authorLee, Seon-Hyeong-
dc.contributor.authorLee, Jae-Seon-
dc.contributor.authorNam, Boas-
dc.contributor.authorSeong, Tae Wha-
dc.contributor.authorSon, Jaekyoung-
dc.contributor.authorJang, Hyonchol-
dc.contributor.authorHong, Kyeong Man-
dc.contributor.authorLee, Cheolju-
dc.contributor.authorKim, Soo-Youl-
dc.date.accessioned2024-01-20T03:33:41Z-
dc.date.available2024-01-20T03:33:41Z-
dc.date.created2021-09-05-
dc.date.issued2016-08-02-
dc.identifier.issn1949-2553-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/123798-
dc.description.abstractAmong ALDH isoforms, ALDH1L1 in the folate pathway showed highly increased expression in non-small-cell lung cancer cells (NSCLC). Based on the basic mechanism of ALDH converting aldehyde to carboxylic acid with by-product NADH, we suggested that ALDH1L1 may contribute to ATP production using NADH through oxidative phosphorylation. ALDH1L1 knockdown reduced ATP production by up to 60% concomitantly with decrease of NADH in NSCLC. ALDH inhibitor, gossypol, also reduced ATP production in a dose dependent manner together with decrease of NADH level in NSCLC. A combination treatment of gossypol with phenformin, mitochondrial complex I inhibitor, synergized ATP depletion, which efficiently induced cell death. Pre-clinical xenograft model using human NSCLC demonstrated a remarkable therapeutic response to the combined treatment of gossypol and phenformin.-
dc.languageEnglish-
dc.publisherIMPACT JOURNALS LLC-
dc.subjectCELL LUNG-CANCER-
dc.subjectLEUKEMIC HL-60 CELLS-
dc.subjectBREAST-CANCER-
dc.subjectMETABOLISM-
dc.subjectGOSSYPOL-
dc.subjectDISEASE-
dc.subjectTRIAL-
dc.subjectGENE-
dc.subjectPHARMACOLOGY-
dc.subjectCARBOPLATIN-
dc.titleAldehyde dehydrogenase inhibition combined with phenformin treatment reversed NSCLC through ATP depletion-
dc.typeArticle-
dc.identifier.doi10.18632/oncotarget.10354-
dc.description.journalClass1-
dc.identifier.bibliographicCitationONCOTARGET, v.7, no.31, pp.49397 - 49410-
dc.citation.titleONCOTARGET-
dc.citation.volume7-
dc.citation.number31-
dc.citation.startPage49397-
dc.citation.endPage49410-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000385422000045-
dc.identifier.scopusid2-s2.0-84981333318-
dc.relation.journalWebOfScienceCategoryOncology-
dc.relation.journalWebOfScienceCategoryCell Biology-
dc.relation.journalResearchAreaOncology-
dc.relation.journalResearchAreaCell Biology-
dc.type.docTypeArticle-
dc.subject.keywordPlusCELL LUNG-CANCER-
dc.subject.keywordPlusLEUKEMIC HL-60 CELLS-
dc.subject.keywordPlusBREAST-CANCER-
dc.subject.keywordPlusMETABOLISM-
dc.subject.keywordPlusGOSSYPOL-
dc.subject.keywordPlusDISEASE-
dc.subject.keywordPlusTRIAL-
dc.subject.keywordPlusGENE-
dc.subject.keywordPlusPHARMACOLOGY-
dc.subject.keywordPlusCARBOPLATIN-
dc.subject.keywordAuthoraldehyde dehydrogenase-
dc.subject.keywordAuthorNSCLC-
dc.subject.keywordAuthorgossypol-
dc.subject.keywordAuthorphenformin-
dc.subject.keywordAuthorcancer metabolism-
Appears in Collections:
KIST Article > 2016
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE