Comparison of the Wound-Healing Effects of Ginsenosides, their Metabolites, and Aglycones

Authors
Park, Jun YeonYou, HwanLee, DahaeHuh, WonsangHwang, Gwi SeoNo, Kyoung TaiKim, Ki HyunHam, JungyeobYamabe, NorikoKim, YounghoonKang, Ki Sung
Issue Date
2016-01
Publisher
WILEY-V C H VERLAG GMBH
Citation
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.37, no.1, pp.52 - 55
Abstract
The effect of ginsenosides, their metabolites, and aglycones on tube formation in human umbilical vein vascular endothelial cells (HUVEC) was investigated to identify ways to potentially enhance wound healing. Of the tested compounds, sapogenins, aglycones of ginsenosides, promoted tube formation, whereas ginsenosides and their metabolites had no effect or inhibitory effects on tube formation. Treatment of HUVEC at concentrations of 6.25 and 12.5 mu M 20(S)-protopanaxadiol (PPD) significantly increased tube formation by 34 and 35%, respectively. PPD also had a pronounced effect on the speed of wound closure in mouse dermal wounds.
Keywords
COMPOUND K; PANAX-GINSENG; ANGIOGENESIS; DEGLYCOSYLATION; EFFICACY; RD; COMPOUND K; PANAX-GINSENG; ANGIOGENESIS; DEGLYCOSYLATION; EFFICACY; RD; Ginsenosides; Tube formation; Sapogenin; Wound healing
ISSN
0253-2964
URI
https://pubs.kist.re.kr/handle/201004/124569
DOI
10.1002/bkcs.10623
Appears in Collections:
KIST Article > 2016
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