DSpace at KISTKIST Article2015

Full metadata record

DC Field Value Language
dc.contributor.authorPark, Cheon-Soo-
dc.contributor.authorAhn, Yongchel-
dc.contributor.authorLee, Dahae-
dc.contributor.authorMoon, Sung Won-
dc.contributor.authorKim, Ki Hyun-
dc.contributor.authorYamabe, Noriko-
dc.contributor.authorHwang, Gwi Seo-
dc.contributor.authorJang, Hyuk Jai-
dc.contributor.authorLee, Heesu-
dc.contributor.authorKang, Ki Sung-
dc.contributor.authorLee, Jae Wook-
dc.date.accessioned2024-01-20T05:31:02Z-
dc.date.available2024-01-20T05:31:02Z-
dc.date.created2021-09-03-
dc.date.issued2015-12-15-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/124622-
dc.description.abstractEight chalcone analogues were prepared and evaluated for their cytotoxic effects in human hepatoma HepG2 cells. Compound 5 had a potent cytotoxic effect. The percentage of apoptotic cells was significantly higher in compound 5-treated cells than in control cells. Exposure to compound 5 for 24 h induced cleavage of caspase-8 and -3, and poly (ADP-ribose) polymerase (PARP). Our findings suggest that compound 5 is the active chalcone analogue that contributes to cell death in HepG2 cells via the extrinsic apoptotic pathway. (C) 2015 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPergamon Press Ltd.-
dc.subjectBIOLOGICAL EVALUATION-
dc.subjectDERIVATIVES-
dc.titleSynthesis of apoptotic chalcone analogues in HepG2 human hepatocellular carcinoma cells-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2015.10.093-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, v.25, no.24, pp.5705 - 5707-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.volume25-
dc.citation.number24-
dc.citation.startPage5705-
dc.citation.endPage5707-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000365032800009-
dc.identifier.scopusid2-s2.0-84947280056-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusBIOLOGICAL EVALUATION-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordAuthorChalcone-
dc.subject.keywordAuthorAnticancer-
dc.subject.keywordAuthorHepG2-
dc.subject.keywordAuthorApoptosis-
Appears in Collections:
KIST Article > 2015
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML
Show Simple Item Record

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE