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dc.contributor.authorKim, Ji-eun-
dc.contributor.authorSeo, Youngmin-
dc.contributor.authorJeong, Yoon-
dc.contributor.authorHwang, Mintai P.-
dc.contributor.authorHwang, Jangsun-
dc.contributor.authorChoo, Jaeburn-
dc.contributor.authorHong, Jong Wook-
dc.contributor.authorJeon, Jun Ho-
dc.contributor.authorRhie, Gi-eun-
dc.contributor.authorChoi, Jonghoon-
dc.date.accessioned2024-01-20T05:34:05Z-
dc.date.available2024-01-20T05:34:05Z-
dc.date.created2022-01-25-
dc.date.issued2015-11-
dc.identifier.issn0304-3894-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/124786-
dc.description.abstractFrancisella tularensis is a human zoonotic pathogen and the causative agent of tularemia, a severe infectious disease. Given the extreme infectivity of F. tularensis and its potential to be used as a biological warfare agent, a fast and sensitive detection method is highly desirable. Herein, we construct a novel detection platform composed of two units: (I) Magnetic beads conjugated with multiple capturing antibodies against F. tularensis for its simple and rapid separation and (2) Genetically-engineered apoferritin protein constructs conjugated with multiple quantum dots and a detection antibody against F. tularensis for the amplification of signal. We demonstrate a 10-fold increase in the sensitivity relative to traditional lateral flow devices that utilize enzyme-based detection methods. We ultimately envision the use of our novel nanoprobe detection platform in future applications that require the highly-sensitive on-site detection of high-risk pathogens. (C) 2015 Elsevier B.V. All rights reserved.-
dc.languageEnglish-
dc.publisherELSEVIER SCIENCE BV-
dc.titleA novel nanoprobe for the sensitive detection of Francisella tularensis-
dc.typeArticle-
dc.identifier.doi10.1016/j.jhazmat.2015.05.041-
dc.description.journalClass1-
dc.identifier.bibliographicCitationJOURNAL OF HAZARDOUS MATERIALS, v.298, pp.188 - 194-
dc.citation.titleJOURNAL OF HAZARDOUS MATERIALS-
dc.citation.volume298-
dc.citation.startPage188-
dc.citation.endPage194-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000360595800021-
dc.identifier.scopusid2-s2.0-84930639081-
dc.relation.journalWebOfScienceCategoryEngineering, Environmental-
dc.relation.journalWebOfScienceCategoryEnvironmental Sciences-
dc.relation.journalResearchAreaEngineering-
dc.relation.journalResearchAreaEnvironmental Sciences & Ecology-
dc.type.docTypeArticle-
dc.subject.keywordPlusNATURAL FOCI-
dc.subject.keywordPlusTULAREMIA-
dc.subject.keywordPlusDIAGNOSIS-
dc.subject.keywordPlusASSAY-
dc.subject.keywordPlusPCR-
dc.subject.keywordPlusNANOPARTICLES-
dc.subject.keywordPlusPLATFORM-
dc.subject.keywordPlusTHERAPY-
dc.subject.keywordPlusCANCER-
dc.subject.keywordPlusAGENTS-
dc.subject.keywordAuthorNanoprobes-
dc.subject.keywordAuthorFrancisella tularensis-
dc.subject.keywordAuthorApoferritin-
dc.subject.keywordAuthorImmunoassay-
dc.subject.keywordAuthorBiosensing-
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KIST Article > 2015
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