Full metadata record

DC Field Value Language
dc.contributor.authorCho, Y.-
dc.contributor.authorLim, J.-H.-
dc.contributor.authorJeong, S.-C.-
dc.contributor.authorSong, M.-K.-
dc.contributor.authorRyu, J.-C.-
dc.date.accessioned2024-01-20T07:02:16Z-
dc.date.available2024-01-20T07:02:16Z-
dc.date.created2021-09-02-
dc.date.issued2015-06-
dc.identifier.issn2005-9752-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/125418-
dc.description.abstractAlthough hexanal is considered to be a major air pollutant the correlation between hexanal and health risk is largely unknown. Identifying aldehyde toxicity in eukaryotic cells will be useful for preventing and treating environmental diseases and disorders. However, it is important to note that previous microRNA (miRNA) studies of hexanal have not yet identified the functional relationship between miRNA and mRNA. The aim of this study is to investigate the modulation of the integrated miRNA-mRNA relationship following exposure to hexanal. A549 human alveolar epithelial cells were treated to a 20% inhibitory concentration (IC20) of hexanal for 48 h. The microarray analysis results showed that 6 miRNA were altered in the hexanal-exposed A549 cells. Integrated analysis of miRNA and mRNA expression profiles identified 445 miRNA-mRNA correlations. KEGG analysis of 445 putative target genes of hexanal-induced miRNAs indicated that 8 genes (ATP2B3, ATP2B4, CACNA1G, EDNRA, GRM5, ITPR2, ITPKB, PTGER3) are involved in the calcium signaling pathway, which plays an important role in Alzheimer’s and several inherited immunodeficiency diseases. Therefore, this study suggests the value of miRNA-mRNA networks in order to identify molecular regulation in response to hexanal exposure in an in vitro model. Furthermore, this approach provides insight into the potential biological process of toxicity and a better understanding of the toxicological mechanism of toxicants. ? 2015, Korean Society of Environmental Risk Assessment and Health Science and Springer Science+Business Media Dordrecht.-
dc.languageEnglish-
dc.publisherKluwer Academic Publishers-
dc.subjecthexanal-
dc.subjectmessenger RNA-
dc.subjectmicroRNA-
dc.subjectair pollutant-
dc.subjectArticle-
dc.subjectATP2B3 gene-
dc.subjectATP2B4 gene-
dc.subjectCACNA1G gene-
dc.subjectcalcium signaling-
dc.subjectEDNRA gene-
dc.subjectgene-
dc.subjectgene control-
dc.subjectgene expression-
dc.subjectgene ontology-
dc.subjectGRM5 gene-
dc.subjecthuman-
dc.subjecthuman cell-
dc.subjectITPKB gene-
dc.subjectITPR2 gene-
dc.subjectmicroarray analysis-
dc.subjectmolecular genetics-
dc.subjectpriority journal-
dc.subjectPTGER3 gene-
dc.subjectEukaryota-
dc.titleHexanal-induced changes in miRNA-mRNA interactions in A549 human alveolar epithelial cells-
dc.typeArticle-
dc.identifier.doi10.1007/s13530-015-0233-1-
dc.description.journalClass1-
dc.identifier.bibliographicCitationToxicology and Environmental Health Sciences, v.7, no.2, pp.143 - 159-
dc.citation.titleToxicology and Environmental Health Sciences-
dc.citation.volume7-
dc.citation.number2-
dc.citation.startPage143-
dc.citation.endPage159-
dc.description.journalRegisteredClassscopus-
dc.identifier.scopusid2-s2.0-84938385860-
dc.type.docTypeArticle-
dc.subject.keywordPlushexanal-
dc.subject.keywordPlusmessenger RNA-
dc.subject.keywordPlusmicroRNA-
dc.subject.keywordPlusair pollutant-
dc.subject.keywordPlusArticle-
dc.subject.keywordPlusATP2B3 gene-
dc.subject.keywordPlusATP2B4 gene-
dc.subject.keywordPlusCACNA1G gene-
dc.subject.keywordPluscalcium signaling-
dc.subject.keywordPlusEDNRA gene-
dc.subject.keywordPlusgene-
dc.subject.keywordPlusgene control-
dc.subject.keywordPlusgene expression-
dc.subject.keywordPlusgene ontology-
dc.subject.keywordPlusGRM5 gene-
dc.subject.keywordPlushuman-
dc.subject.keywordPlushuman cell-
dc.subject.keywordPlusITPKB gene-
dc.subject.keywordPlusITPR2 gene-
dc.subject.keywordPlusmicroarray analysis-
dc.subject.keywordPlusmolecular genetics-
dc.subject.keywordPluspriority journal-
dc.subject.keywordPlusPTGER3 gene-
dc.subject.keywordPlusEukaryota-
dc.subject.keywordAuthorAldehydes-
dc.subject.keywordAuthorCalcium signaling-
dc.subject.keywordAuthorHexanal-
dc.subject.keywordAuthorMicroarray-
dc.subject.keywordAuthorMicroRNA-
dc.subject.keywordAuthorTarget mRNA-
Appears in Collections:
KIST Article > 2015
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE