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dc.contributor.authorKim, Hyoung Ja-
dc.contributor.authorKim, Seung Hwan-
dc.contributor.authorLee, Young Hun-
dc.contributor.authorKim, Dong Woon-
dc.contributor.authorMo, Kilwoong-
dc.contributor.authorKim, Hye Jin-
dc.contributor.authorPark, Sang Hoon-
dc.contributor.authorJin, Changbae-
dc.contributor.authorKim, Nam-Jung-
dc.contributor.authorLee, Yong Sup-
dc.date.accessioned2024-01-20T07:04:11Z-
dc.date.available2024-01-20T07:04:11Z-
dc.date.created2021-09-05-
dc.date.issued2015-05-
dc.identifier.issn0253-2964-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/125514-
dc.description.abstractRecently, many reports revealed that there are close correlations between antioxidant and anticancer activities of compounds. In this study, we designed 4-hydroxy-3,4-dihydroxychalcone (2) as a ring-opened analog of luteolin, which has been known to possess both antioxidant and anticancer activities, and then introduced aminoethyl moieties to this chalcone structure to increase water solubility by transforming into HCl salts. Synthesized aminoalkyl-substituted chalcones 3a-3d showed potent antioxidant activities in three different assay systems and anticancer activities against four tumor cell lines tested.-
dc.languageEnglish-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.subjectCHALCONE DERIVATIVES-
dc.subjectANTICANCER ACTIVITY-
dc.subjectCANCER-
dc.titleSynthesis of 4-(2-Amino) ethoxy-3 ',4 '-dihydroxychalcones and Their Antioxidant and Cytotoxic Effects on Human Tumor Cells-
dc.typeArticle-
dc.identifier.doi10.1002/bkcs.10253-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.36, no.5, pp.1335 - 1339-
dc.citation.titleBULLETIN OF THE KOREAN CHEMICAL SOCIETY-
dc.citation.volume36-
dc.citation.number5-
dc.citation.startPage1335-
dc.citation.endPage1339-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.identifier.kciidART001990578-
dc.identifier.wosid000354133600007-
dc.identifier.scopusid2-s2.0-84936869007-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusCHALCONE DERIVATIVES-
dc.subject.keywordPlusANTICANCER ACTIVITY-
dc.subject.keywordPlusCANCER-
dc.subject.keywordAuthorChalcone-
dc.subject.keywordAuthorAminoethyl-
dc.subject.keywordAuthorAntioxidant-
dc.subject.keywordAuthorCytotoxicity-
dc.subject.keywordAuthorSolubility-
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