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dc.contributor.authorLee, Kyung-Mi-
dc.contributor.authorYun, Ji Ho-
dc.contributor.authorLee, Dong Hwa-
dc.contributor.authorPark, Young Gyun-
dc.contributor.authorSon, Kun Ho-
dc.contributor.authorNho, Chu Won-
dc.contributor.authorKim, Yeong Shik-
dc.date.accessioned2024-01-20T07:04:42Z-
dc.date.available2024-01-20T07:04:42Z-
dc.date.created2021-09-05-
dc.date.issued2015-04-17-
dc.identifier.issn0006-291X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/125539-
dc.description.abstractWe demonstrate that chikusetsusaponin IVa methyl ester (CME), a triterpenoid saponin from the root of Achyranthes japonica, has an anticancer activity. We investigate its molecular mechanism in depth in HCT116 cells. CME reduces the amount of beta-catenin in nucleus and inhibits the binding of beta-catenin to specific DNA sequences (TCF binding elements, TBE) in target gene promoters. Thus, CME appears to decrease the expression of cell cycle regulatory proteins such as Cyclin D1, as a representative target for beta-catenin, as well as CDK2 and CDK4. As a result of the decrease of the cell cycle regulatory proteins, CME inhibits cell proliferation by arresting the cell cycle at the G0/G1 phase. Therefore, we suggest that CME as a novel Wnt/beta-catenin inhibitor can be a putative agent for the treatment of colorectal cancers. (C) 2015 Elsevier Inc. All rights reserved.-
dc.languageEnglish-
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE-
dc.subjectGASTRIC-CANCER CELLS-
dc.subjectCOLORECTAL-CANCER-
dc.subjectSIGNALING PATHWAY-
dc.subjectCOLON-CANCER-
dc.subjectAPC GENE-
dc.subjectWNT-
dc.subjectAPOPTOSIS-
dc.subjectGROWTH-
dc.subjectMUTATIONS-
dc.subjectACTIVATION-
dc.titleChikusetsusaponin IVa methyl ester induces cell cycle arrest by the inhibition of nuclear translocation of beta-catenin in HCT116 cells-
dc.typeArticle-
dc.identifier.doi10.1016/j.bbrc.2015.02.152-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.459, no.4, pp.591 - 596-
dc.citation.titleBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.citation.volume459-
dc.citation.number4-
dc.citation.startPage591-
dc.citation.endPage596-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000352922200006-
dc.identifier.scopusid2-s2.0-84930738982-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryBiophysics-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaBiophysics-
dc.type.docTypeArticle-
dc.subject.keywordPlusGASTRIC-CANCER CELLS-
dc.subject.keywordPlusCOLORECTAL-CANCER-
dc.subject.keywordPlusSIGNALING PATHWAY-
dc.subject.keywordPlusCOLON-CANCER-
dc.subject.keywordPlusAPC GENE-
dc.subject.keywordPlusWNT-
dc.subject.keywordPlusAPOPTOSIS-
dc.subject.keywordPlusGROWTH-
dc.subject.keywordPlusMUTATIONS-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordAuthorChikusetsusaponin IVa methyl ester-
dc.subject.keywordAuthorbeta-catenin-
dc.subject.keywordAuthorCell cycle arrest-
dc.subject.keywordAuthorApoptosis-
dc.subject.keywordAuthorWnt-
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