Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Lee, Kyung-Mi | - |
dc.contributor.author | Yun, Ji Ho | - |
dc.contributor.author | Lee, Dong Hwa | - |
dc.contributor.author | Park, Young Gyun | - |
dc.contributor.author | Son, Kun Ho | - |
dc.contributor.author | Nho, Chu Won | - |
dc.contributor.author | Kim, Yeong Shik | - |
dc.date.accessioned | 2024-01-20T07:04:42Z | - |
dc.date.available | 2024-01-20T07:04:42Z | - |
dc.date.created | 2021-09-05 | - |
dc.date.issued | 2015-04-17 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://pubs.kist.re.kr/handle/201004/125539 | - |
dc.description.abstract | We demonstrate that chikusetsusaponin IVa methyl ester (CME), a triterpenoid saponin from the root of Achyranthes japonica, has an anticancer activity. We investigate its molecular mechanism in depth in HCT116 cells. CME reduces the amount of beta-catenin in nucleus and inhibits the binding of beta-catenin to specific DNA sequences (TCF binding elements, TBE) in target gene promoters. Thus, CME appears to decrease the expression of cell cycle regulatory proteins such as Cyclin D1, as a representative target for beta-catenin, as well as CDK2 and CDK4. As a result of the decrease of the cell cycle regulatory proteins, CME inhibits cell proliferation by arresting the cell cycle at the G0/G1 phase. Therefore, we suggest that CME as a novel Wnt/beta-catenin inhibitor can be a putative agent for the treatment of colorectal cancers. (C) 2015 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | GASTRIC-CANCER CELLS | - |
dc.subject | COLORECTAL-CANCER | - |
dc.subject | SIGNALING PATHWAY | - |
dc.subject | COLON-CANCER | - |
dc.subject | APC GENE | - |
dc.subject | WNT | - |
dc.subject | APOPTOSIS | - |
dc.subject | GROWTH | - |
dc.subject | MUTATIONS | - |
dc.subject | ACTIVATION | - |
dc.title | Chikusetsusaponin IVa methyl ester induces cell cycle arrest by the inhibition of nuclear translocation of beta-catenin in HCT116 cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bbrc.2015.02.152 | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.459, no.4, pp.591 - 596 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 459 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 591 | - |
dc.citation.endPage | 596 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.wosid | 000352922200006 | - |
dc.identifier.scopusid | 2-s2.0-84930738982 | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | GASTRIC-CANCER CELLS | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | COLON-CANCER | - |
dc.subject.keywordPlus | APC GENE | - |
dc.subject.keywordPlus | WNT | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | Chikusetsusaponin IVa methyl ester | - |
dc.subject.keywordAuthor | beta-catenin | - |
dc.subject.keywordAuthor | Cell cycle arrest | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Wnt | - |
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