Full metadata record

DC Field Value Language
dc.contributor.authorMa, Dongliang-
dc.contributor.authorYoon, Su-In-
dc.contributor.authorYang, Chih-Hao-
dc.contributor.authorMarcy, Guillaume-
dc.contributor.authorZhao, Na-
dc.contributor.authorLeong, Wan-Ying-
dc.contributor.authorGanapathy, Vinu-
dc.contributor.authorHan, Ju-
dc.contributor.authorVan Dongen, Antonius M. J.-
dc.contributor.authorHsu, Kuei-Sen-
dc.contributor.authorMing, Guo-Li-
dc.contributor.authorAugustine, George J.-
dc.contributor.authorGoh, Eyleen L. K.-
dc.date.accessioned2024-01-20T07:30:28Z-
dc.date.available2024-01-20T07:30:28Z-
dc.date.created2022-01-25-
dc.date.issued2015-04-
dc.identifier.issn1933-7213-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/125568-
dc.description.abstractRett syndrome is a neurodevelopmental disorder that usually arises from mutations or deletions in methyl-CpG binding protein 2 (MeCP2), a transcriptional regulator that affects neuronal development and maturation without causing cell loss. Here, we show that silencing of MeCP2 decreased neurite arborization and synaptogenesis in cultured hippocampal neurons from rat fetal brains. These structural defects were associated with alterations in synaptic transmission and neural network activity. Similar retardation of dendritic growth was also observed in MeCP2-deficient newborn granule cells in the dentate gyrus of adult mouse brains in vivo, demonstrating direct and cell-autonomous effects on individual neurons. These defects, caused by MeCP2 deficiency, were reversed by treatment with the US Food and Drug Administration-approved drug, pentobarbital, in vitro and in vivo, possibly caused by modulation of gamma-aminobutyric acid signaling. The results indicate that drugs modulating gamma-aminobutyric acid signaling are potential therapeutics for Rett syndrome.-
dc.languageEnglish-
dc.publisherSPRINGER-
dc.titleRescue of Methyl-CpG Binding Protein 2 Dysfunction-induced Defects in Newborn Neurons by Pentobarbital-
dc.typeArticle-
dc.identifier.doi10.1007/s13311-015-0343-0-
dc.description.journalClass1-
dc.identifier.bibliographicCitationNEUROTHERAPEUTICS, v.12, no.2, pp.477 - 490-
dc.citation.titleNEUROTHERAPEUTICS-
dc.citation.volume12-
dc.citation.number2-
dc.citation.startPage477-
dc.citation.endPage490-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000353223000019-
dc.identifier.scopusid2-s2.0-84939968942-
dc.relation.journalWebOfScienceCategoryClinical Neurology-
dc.relation.journalWebOfScienceCategoryNeurosciences-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.relation.journalResearchAreaNeurosciences & Neurology-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.type.docTypeArticle-
dc.subject.keywordPlusMECP2 MUTANT MICE-
dc.subject.keywordPlusRETT-SYNDROME-
dc.subject.keywordPlusMOUSE MODEL-
dc.subject.keywordPlusTRANSCRIPTIONAL REPRESSOR-
dc.subject.keywordPlusSYNAPTIC PLASTICITY-
dc.subject.keywordPlusHIPPOCAMPAL-NEURONS-
dc.subject.keywordPlusNONSENSE MUTATIONS-
dc.subject.keywordPlusCA2+ OSCILLATIONS-
dc.subject.keywordPlusBRAIN-
dc.subject.keywordPlusGABA(A)-
dc.subject.keywordAuthorRett syndrome-
dc.subject.keywordAuthornewborn neurons-
dc.subject.keywordAuthordendrites-
dc.subject.keywordAuthorGABA-
dc.subject.keywordAuthorpentobarbital-
Appears in Collections:
KIST Article > 2015
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE