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dc.contributor.authorKim, Younghee-
dc.contributor.authorSon, Jiwon-
dc.contributor.authorKim, Juhyeon-
dc.contributor.authorBaek, Du-Jong-
dc.contributor.authorLee, Yong Sup-
dc.contributor.authorLim, Eun Jeong-
dc.contributor.authorLee, Jae Kyun-
dc.contributor.authorPae, Ae Nim-
dc.contributor.authorMin, Sun-Joon-
dc.contributor.authorCho, Yong Seo-
dc.date.accessioned2024-01-20T09:34:27Z-
dc.date.available2024-01-20T09:34:27Z-
dc.date.created2021-09-04-
dc.date.issued2014-06-
dc.identifier.issn0009-2363-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/126765-
dc.description.abstractA series of 2-amino and 2-methoxy quinoline-6-carboxamide derivatives have been synthesized and their metabotropic glutamate receptor type 1 (mGluR1) antagonistic activities were evaluated in a functional cell-based assay. The compound 13c showed the highest potency with IC50 value of 2.16 mu m against mGluR1. Finally, in vivo evaluation of 13c in the rat spinal nerve ligation (SNL) model exhibited weak analgesic effects with regard to both mechanical allodynia and cold allodynia.-
dc.languageEnglish-
dc.publisherPHARMACEUTICAL SOC JAPAN-
dc.subjectMETABOTROPIC GLUTAMATE RECEPTORS-
dc.subjectGLUTAMATE-RECEPTOR-1 ANTAGONISTS-
dc.subjectPHARMACOLOGICAL CHARACTERIZATION-
dc.subjectIN-VITRO-
dc.subjectDERIVATIVES-
dc.subjectDISCOVERY-
dc.subjectMICE-
dc.subjectPROFILES-
dc.subjectLY456236-
dc.subjectEFFICACY-
dc.titleSynthesis and Biological Evaluation of 2-Substituted Quinoline 6-Carboxamides as Potential mGluR1 Antagonists for the Treatment of Neuropathic Pain-
dc.typeArticle-
dc.identifier.doi10.1248/cpb.c13-00945-
dc.description.journalClass1-
dc.identifier.bibliographicCitationCHEMICAL & PHARMACEUTICAL BULLETIN, v.62, no.6, pp.508 - 518-
dc.citation.titleCHEMICAL & PHARMACEUTICAL BULLETIN-
dc.citation.volume62-
dc.citation.number6-
dc.citation.startPage508-
dc.citation.endPage518-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000336559100002-
dc.identifier.scopusid2-s2.0-84903395807-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusMETABOTROPIC GLUTAMATE RECEPTORS-
dc.subject.keywordPlusGLUTAMATE-RECEPTOR-1 ANTAGONISTS-
dc.subject.keywordPlusPHARMACOLOGICAL CHARACTERIZATION-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusDISCOVERY-
dc.subject.keywordPlusMICE-
dc.subject.keywordPlusPROFILES-
dc.subject.keywordPlusLY456236-
dc.subject.keywordPlusEFFICACY-
dc.subject.keywordAuthorglutamate-
dc.subject.keywordAuthormetabotropic glutamate receptor (mGluR)-
dc.subject.keywordAuthorquinoline-
dc.subject.keywordAuthorneuropathic pain-
dc.subject.keywordAuthorspinal nerve ligation (SNL) model-
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