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dc.contributor.authorLee, Sang-Hyun-
dc.contributor.authorKim, YoungSoo-
dc.contributor.authorKim, Hye Yun-
dc.contributor.authorKim, Young Hoon-
dc.contributor.authorKim, Maeng Sup-
dc.contributor.authorKong, Jae Yang-
dc.contributor.authorLee, Mun-Han-
dc.contributor.authorKim, Dong Jin-
dc.contributor.authorAhn, Young Gil-
dc.date.accessioned2024-01-20T10:01:37Z-
dc.date.available2024-01-20T10:01:37Z-
dc.date.created2021-09-05-
dc.date.issued2014-04-23-
dc.identifier.issn1932-6203-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/126870-
dc.description.abstractAlzheimer's disease is an irreversible neurodegenerative disorder that is characterized by the abnormal aggregation of amyloid-beta into neurotoxic oligomers and plaques. Although many disease-modifying molecules are currently in Alzheimer clinical trials, a small molecule that inhibits amyloid-b aggregation and ameliorates the disorder has not been approved to date. Herein, we report the effects of a potent small molecule, 6-methoxy-2-(4-dimethylaminostyryl) benzofuran (KMS88009), that directly disrupts amyloid-b oligomerization, preserving cognitive behavior when used prophylactically and reversing declines in cognitive behavior when used therapeutically. KMS88009 exhibited excellent pharmacokinetic profiles with extensive brain uptake and a high level of safety. When orally administered before and after the onset of Alzheimer's disease symptoms, KMS88009 significantly reduced assembly of amyloid-b oligomers and improved cognitive behaviors in the APP/ PS1 double transgenic mouse model. The unique dual mode of action indicates that KMS88009 may be a powerful therapeutic candidate for the treatment of Alzheimer's disease.-
dc.languageEnglish-
dc.publisherPUBLIC LIBRARY SCIENCE-
dc.subjectMOUSE MODEL-
dc.subjectDISEASE-
dc.subjectSTRATEGIES-
dc.subjectIMPAIRMENT-
dc.subjectINHIBITORS-
dc.subjectCASCADE-
dc.subjectMEMORY-
dc.titleAminostyrylbenzofuran Directly Reduces Oligomeric Amyloid-beta and Reverses Cognitive Deficits in Alzheimer Transgenic Mice-
dc.typeArticle-
dc.identifier.doi10.1371/journal.pone.0095733-
dc.description.journalClass1-
dc.identifier.bibliographicCitationPLOS ONE, v.9, no.4-
dc.citation.titlePLOS ONE-
dc.citation.volume9-
dc.citation.number4-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000335298200083-
dc.identifier.scopusid2-s2.0-84899720596-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.type.docTypeArticle-
dc.subject.keywordPlusMOUSE MODEL-
dc.subject.keywordPlusDISEASE-
dc.subject.keywordPlusSTRATEGIES-
dc.subject.keywordPlusIMPAIRMENT-
dc.subject.keywordPlusINHIBITORS-
dc.subject.keywordPlusCASCADE-
dc.subject.keywordPlusMEMORY-
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KIST Article > 2014
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