Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Lee, Sang-Hyun | - |
dc.contributor.author | Kim, YoungSoo | - |
dc.contributor.author | Kim, Hye Yun | - |
dc.contributor.author | Kim, Young Hoon | - |
dc.contributor.author | Kim, Maeng Sup | - |
dc.contributor.author | Kong, Jae Yang | - |
dc.contributor.author | Lee, Mun-Han | - |
dc.contributor.author | Kim, Dong Jin | - |
dc.contributor.author | Ahn, Young Gil | - |
dc.date.accessioned | 2024-01-20T10:01:37Z | - |
dc.date.available | 2024-01-20T10:01:37Z | - |
dc.date.created | 2021-09-05 | - |
dc.date.issued | 2014-04-23 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://pubs.kist.re.kr/handle/201004/126870 | - |
dc.description.abstract | Alzheimer's disease is an irreversible neurodegenerative disorder that is characterized by the abnormal aggregation of amyloid-beta into neurotoxic oligomers and plaques. Although many disease-modifying molecules are currently in Alzheimer clinical trials, a small molecule that inhibits amyloid-b aggregation and ameliorates the disorder has not been approved to date. Herein, we report the effects of a potent small molecule, 6-methoxy-2-(4-dimethylaminostyryl) benzofuran (KMS88009), that directly disrupts amyloid-b oligomerization, preserving cognitive behavior when used prophylactically and reversing declines in cognitive behavior when used therapeutically. KMS88009 exhibited excellent pharmacokinetic profiles with extensive brain uptake and a high level of safety. When orally administered before and after the onset of Alzheimer's disease symptoms, KMS88009 significantly reduced assembly of amyloid-b oligomers and improved cognitive behaviors in the APP/ PS1 double transgenic mouse model. The unique dual mode of action indicates that KMS88009 may be a powerful therapeutic candidate for the treatment of Alzheimer's disease. | - |
dc.language | English | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.subject | MOUSE MODEL | - |
dc.subject | DISEASE | - |
dc.subject | STRATEGIES | - |
dc.subject | IMPAIRMENT | - |
dc.subject | INHIBITORS | - |
dc.subject | CASCADE | - |
dc.subject | MEMORY | - |
dc.title | Aminostyrylbenzofuran Directly Reduces Oligomeric Amyloid-beta and Reverses Cognitive Deficits in Alzheimer Transgenic Mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.1371/journal.pone.0095733 | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.9, no.4 | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 9 | - |
dc.citation.number | 4 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.wosid | 000335298200083 | - |
dc.identifier.scopusid | 2-s2.0-84899720596 | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | STRATEGIES | - |
dc.subject.keywordPlus | IMPAIRMENT | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordPlus | CASCADE | - |
dc.subject.keywordPlus | MEMORY | - |
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