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dc.contributor.authorViswanath, Ambily Nath Indu-
dc.contributor.authorPae, Ae Nim-
dc.date.accessioned2024-01-20T11:34:38Z-
dc.date.available2024-01-20T11:34:38Z-
dc.date.created2021-09-04-
dc.date.issued2013-08-22-
dc.identifier.issn0022-2623-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/127761-
dc.description.abstractTalapatra et al. elucidated the molecular basis of resistance by characterizing the binding interactions between Eg5 and the allosteric inhibitor SB743921. The investigation, employing biochemical, biophysical, and structural analyses, made path-breaking revelations in Eg5 studies and discussed a novel phenomenon "resistance by allostery", which could have far-reaching consequences from a rational drug design perspective.-
dc.languageEnglish-
dc.publisherAMER CHEMICAL SOC-
dc.subjectPHASE-II-
dc.subjectINHIBITOR-
dc.subjectPHARMACOKINETICS-
dc.subjectCARCINOMA-
dc.subjectISPINESIB-
dc.subjectSB-715992-
dc.subjectRECURRENT-
dc.subjectEG5-
dc.titleResistance by Allostery: A Novel Perspective for Eg5-Targeted Drug Design-
dc.typeArticle-
dc.identifier.doi10.1021/jm401071u-
dc.description.journalClass1-
dc.identifier.bibliographicCitationJOURNAL OF MEDICINAL CHEMISTRY, v.56, no.16, pp.6314 - 6316-
dc.citation.titleJOURNAL OF MEDICINAL CHEMISTRY-
dc.citation.volume56-
dc.citation.number16-
dc.citation.startPage6314-
dc.citation.endPage6316-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000323593400003-
dc.identifier.scopusid2-s2.0-84883163795-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.type.docTypeArticle-
dc.subject.keywordPlusPHASE-II-
dc.subject.keywordPlusINHIBITOR-
dc.subject.keywordPlusPHARMACOKINETICS-
dc.subject.keywordPlusCARCINOMA-
dc.subject.keywordPlusISPINESIB-
dc.subject.keywordPlusSB-715992-
dc.subject.keywordPlusRECURRENT-
dc.subject.keywordPlusEG5-
dc.subject.keywordAuthorEg5-
dc.subject.keywordAuthorKinesin Spindle Protein-
dc.subject.keywordAuthorAllostery-
dc.subject.keywordAuthoranticancer-
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