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dc.contributor.authorDevegowda, Vani Nelamane-
dc.contributor.authorHong, Jin-Ri-
dc.contributor.authorCho, Sungjin-
dc.contributor.authorLim, Eun Jeong-
dc.contributor.authorChoo, Hyunah-
dc.contributor.authorKeum, Gyochang-
dc.contributor.authorRhim, Hyewon-
dc.contributor.authorNam, Ghilsoo-
dc.date.accessioned2024-01-20T11:34:47Z-
dc.date.available2024-01-20T11:34:47Z-
dc.date.created2021-09-05-
dc.date.issued2013-08-15-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/127769-
dc.description.abstractA novel series of 3-arylsulfonylamino-5,6-dihydro-6-substituted-1H-pyrazolo[3,4-c]pyridine-7-ones was designed and synthesized as 5-HT6 ligands. Among the derivatives synthesized, the lead compound, 12b, having piperidine functionality at the 6-position and (1-naphthyl)sulfonamino at the 3-position of the core structure showed the most potent 5-HT6 inhibitory activity in vitro, good stability without CYP liability, and good neuropathic pain alleviation activity in a rat animal model. (C) 2013 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPergamon Press Ltd.-
dc.subjectSEROTONIN-
dc.subjectDERIVATIVES-
dc.subjectBINDING-
dc.subjectMODEL-
dc.titleSynthesis and the 5-HT6 receptor antagonistic effect of 3-arylsulfonylamino-5,6-dihydro-6-substituted pyrazolo[3,4]pyridinones for neuropathic pain treatment-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2013.05.100-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, v.23, no.16, pp.4696 - 4700-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.volume23-
dc.citation.number16-
dc.citation.startPage4696-
dc.citation.endPage4700-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000322611900040-
dc.identifier.scopusid2-s2.0-84880601634-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusSEROTONIN-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusBINDING-
dc.subject.keywordPlusMODEL-
dc.subject.keywordAuthorArylsufonylamino-5,6-dihydro-pyrazolo[3,4-c]pyridine-7-one-
dc.subject.keywordAuthorSynthesis-
dc.subject.keywordAuthor5-HT6 receptor antagonist-
dc.subject.keywordAuthorNeuropathic pain-
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